T-lymphocyte studies for a subset of 14 rituximab-related PML cases
| Case . | Indication . | CD4+ cells/μL . | CD8+ cells/μL . | CD4/CD8 ratio . | Hematopoietic transplantation . | Purine analog exposure . | Survival . |
|---|---|---|---|---|---|---|---|
| 1 | Diffuse large B-cell lymphoma | 68 | NA | NA | None | No | No |
| 2 | Systemic lupus erythematosus | 71 | 57 | 1.25 | None | No | No |
| 3 | Non-Hodgkin lymphoma | 89 | 41 | 2.17 | Autologous | No | No |
| 4 | Diffuse large B-cell lymphoma | 94 | 243 | 0.39 | None | No | No |
| 5 | Mantle cell lymphoma | 110 | 310 | 0.35 | None | No | No |
| 6 | Follicular lymphoma | 152 | 532 | 0.29 | None | No | No |
| 7 | Follicular lymphoma | 234 | 1015 | 0.23 | Autologous | No | No |
| 8 | Chronic lymphocytic leukemia | 287 | 311 | 0.92 | None | No | Yes |
| 9 | Mantle cell lymphoma | 403 | 1309 | 0.31 | Allogeneic | No | No |
| 10 | Marginal zone B-cell lymphoma | 551 | 2596 | 0.21 | Autologous | No | Yes |
| 11 | Autoimmune hemolytic anemia | 562 | 382 | 1.47 | None | No | No |
| 12 | Follicular lymphoma | 570 | 1871 | 0.30 | None | No | No |
| 13 | Autoimmune hemolytic anemia | 1059 | 3453 | 0.31 | Allogeneic | No | Yes |
| 14 | Waldenstrom macroglobulinemia | 2100 | 6200 | 0.34 | None | Yes | No |
| Case . | Indication . | CD4+ cells/μL . | CD8+ cells/μL . | CD4/CD8 ratio . | Hematopoietic transplantation . | Purine analog exposure . | Survival . |
|---|---|---|---|---|---|---|---|
| 1 | Diffuse large B-cell lymphoma | 68 | NA | NA | None | No | No |
| 2 | Systemic lupus erythematosus | 71 | 57 | 1.25 | None | No | No |
| 3 | Non-Hodgkin lymphoma | 89 | 41 | 2.17 | Autologous | No | No |
| 4 | Diffuse large B-cell lymphoma | 94 | 243 | 0.39 | None | No | No |
| 5 | Mantle cell lymphoma | 110 | 310 | 0.35 | None | No | No |
| 6 | Follicular lymphoma | 152 | 532 | 0.29 | None | No | No |
| 7 | Follicular lymphoma | 234 | 1015 | 0.23 | Autologous | No | No |
| 8 | Chronic lymphocytic leukemia | 287 | 311 | 0.92 | None | No | Yes |
| 9 | Mantle cell lymphoma | 403 | 1309 | 0.31 | Allogeneic | No | No |
| 10 | Marginal zone B-cell lymphoma | 551 | 2596 | 0.21 | Autologous | No | Yes |
| 11 | Autoimmune hemolytic anemia | 562 | 382 | 1.47 | None | No | No |
| 12 | Follicular lymphoma | 570 | 1871 | 0.30 | None | No | No |
| 13 | Autoimmune hemolytic anemia | 1059 | 3453 | 0.31 | Allogeneic | No | Yes |
| 14 | Waldenstrom macroglobulinemia | 2100 | 6200 | 0.34 | None | Yes | No |
The normal CD4+ range is 500 to 1600 cells/μL; the normal CD8+ range is 400 to 1100 cells/μL; the normal CD4/CD8 ratio is 0.8 to 2.7.
NA indicates not applicable.