Outcome of transfusions from scrapie-exposed donor sheep
| Donor sheep details . | Recipient sheep details . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor sheep ID . | Donor genotype . | Clinical status at donation . | Percentage of actual or average incubation period at donation* . | Clinical outcome . | IHC result . | Incubation period, d . | Component transfused . | Recipient sheep ID . | Clinical outcome . | IHC result . | Incubation period, d . |
| 67x42 | VRQ/VRQ | Preclinical | 17 | + | + | 1274 | BC | G247 | − | − | − |
| 19 | WB | G230 | − | − | − | ||||||
| 66x45 | VRQ/VRQ | Preclinical | 17 | − | − | − | WB | G267 | − | − | − |
| 19 | BC | G265 | − | − | − | ||||||
| 67x23 | VRQ/VRQ | Preclinical | 18 | + | + | 1207 | BC | G241 | − | − | − |
| 20 | WB | G228 | − | − | − | ||||||
| 65x13 | VRQ/VRQ | Preclinical | 28 | + | + | 1556 | WB | F275 | − | − | − |
| 30 | BC | F273 | − | − | − | ||||||
| 65x02 | VRQ/VRQ | Preclinical | 34 | − | + | − | WB | F310 | − | − | − |
| 37 | BC | F309 | + | + | 1101 | ||||||
| 65x03 | VRQ/VRQ | Preclinical | 34 | − | + | − | WB | F277 | + | + | 1138 |
| 37 | BC | F276 | +† | − | − | ||||||
| 61x75 | VRQ/ARQ | Preclinical | 53 | + | + | 1324 | BC | F149 | + | + | 782 |
| 57 | WB | F144 | + | + | 672 | ||||||
| 61x68 | VRQ/VRQ | Preclinical | 64 | + | + | 1113 | BC | F152 | + | + | 853 |
| 69 | WB | F153 | + | + | 660 | ||||||
| 61x66 | VRQ/VRQ | Preclinical | 62 | − | ND | − | WB | F286 | − | − | − |
| 64 | BC | F284 | − | − | − | ||||||
| 59x27 | VRQ/VRQ | Preclinical | 73 | + | + | 1137 | BC | F126 | + | + | 826 |
| 77 | WB | F141 | + | + | 575 | ||||||
| 59x28 | VRQ/VRQ | Clinical | 100 | + | + | 1081 | BC | F143 | + | + | 737 |
| Donor sheep details . | Recipient sheep details . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor sheep ID . | Donor genotype . | Clinical status at donation . | Percentage of actual or average incubation period at donation* . | Clinical outcome . | IHC result . | Incubation period, d . | Component transfused . | Recipient sheep ID . | Clinical outcome . | IHC result . | Incubation period, d . |
| 67x42 | VRQ/VRQ | Preclinical | 17 | + | + | 1274 | BC | G247 | − | − | − |
| 19 | WB | G230 | − | − | − | ||||||
| 66x45 | VRQ/VRQ | Preclinical | 17 | − | − | − | WB | G267 | − | − | − |
| 19 | BC | G265 | − | − | − | ||||||
| 67x23 | VRQ/VRQ | Preclinical | 18 | + | + | 1207 | BC | G241 | − | − | − |
| 20 | WB | G228 | − | − | − | ||||||
| 65x13 | VRQ/VRQ | Preclinical | 28 | + | + | 1556 | WB | F275 | − | − | − |
| 30 | BC | F273 | − | − | − | ||||||
| 65x02 | VRQ/VRQ | Preclinical | 34 | − | + | − | WB | F310 | − | − | − |
| 37 | BC | F309 | + | + | 1101 | ||||||
| 65x03 | VRQ/VRQ | Preclinical | 34 | − | + | − | WB | F277 | + | + | 1138 |
| 37 | BC | F276 | +† | − | − | ||||||
| 61x75 | VRQ/ARQ | Preclinical | 53 | + | + | 1324 | BC | F149 | + | + | 782 |
| 57 | WB | F144 | + | + | 672 | ||||||
| 61x68 | VRQ/VRQ | Preclinical | 64 | + | + | 1113 | BC | F152 | + | + | 853 |
| 69 | WB | F153 | + | + | 660 | ||||||
| 61x66 | VRQ/VRQ | Preclinical | 62 | − | ND | − | WB | F286 | − | − | − |
| 64 | BC | F284 | − | − | − | ||||||
| 59x27 | VRQ/VRQ | Preclinical | 73 | + | + | 1137 | BC | F126 | + | + | 826 |
| 77 | WB | F141 | + | + | 575 | ||||||
| 59x28 | VRQ/VRQ | Clinical | 100 | + | + | 1081 | BC | F143 | + | + | 737 |
+ indicates positive; and −, negative.
Calculated from the age at the time of donation, as a percentage either of the final incubation period (for sheep that survived until the development of clinical signs) or of the average incubation period (1296 days) for sheep that died or were culled before developing clinical signs.
No evidence of infection was found on postmortem examination of tissues from this clinical suspect; therefore, it is most likely it was clinically misdiagnosed.