Table 4

Univariate analysis of change in WBC counts, platelet counts, and hemoglobin levels of unrelated PBSC donors facilitated by the NMDP, 1999-2004

nMean95% CIP
Change in WBC, from baseline, ×109/L     
    Day 5 before apheresis 2323 32.61 (32.14 to 33.09) < .001 
    1 mo after donation 1998 −0.506 (−0.578 to −0.434) < .001 
    1 y after donation 1645 0.121 (0.041 to 0.202) .003 
    2 y after donation 1321 0.230 (0.145 to 0.316) < .001 
    3 y after donation 1123 0.271 (0.173 to 0.369) < .001 
    4 y after donation 695 0.288 (0.164 to 0.412) < .001 
From before apheresis to after apheresis     
    Day 5 2316 −3.674 (−4.043 to −3.305) < .001 
    Day 6 1560 −9.725 (−9.980 to −9.470) < .001 
Change in platelets, from baseline, ×109/L     
    Day 5 before apheresis 2317 −10.01 (−11.32 to −8.693) < .001 
    1 mo after donation 1992 −6.169 (−7.823 to −4.515) < .001 
    1 y after donation 1640 1.084 (−0.652 to 2.819) .22 
    2 y after donation 1314 2.276 (0.190 to 4.361) .033 
    3 y after donation 1120 1.610 (−0.604 to 3.824) .15 
    4 y after donation 695 −0.135 (−3.051 to 2.78) .93 
From before apheresis to after apheresis     
    Day 5 2311 −92.28 (−94.07 to −90.49) < .001 
    Day 6 1557 −53.38 (−54.60 to −52.17) < .001 
Change in hemoglobin, from baseline, g/L     
    Day 5 before apheresis 2311 −2.02 (−2.31 to −1.73) < .001 
    1 mo after donation 1992 −2.99 (−3.31 to −2.67) < .001 
    1 y after donation 1637 −0.56 (−0.97 to −0.14) .009 
    2 y after donation 1315 −0.28 (−0.77 to 0.22) .28 
    3 y after donation 1121 −0.09 (−0.63 to 0.45) .74 
    4 y after donation 694 0.50 (−0.23 to 1.23) .18 
From before apheresis to after apheresis     
    Day 5 2291 −11.69 (−11.94 to −11.44) < .001 
    Day 6 1536 −10.41 (−10.73 to −10.10) < .001 
nMean95% CIP
Change in WBC, from baseline, ×109/L     
    Day 5 before apheresis 2323 32.61 (32.14 to 33.09) < .001 
    1 mo after donation 1998 −0.506 (−0.578 to −0.434) < .001 
    1 y after donation 1645 0.121 (0.041 to 0.202) .003 
    2 y after donation 1321 0.230 (0.145 to 0.316) < .001 
    3 y after donation 1123 0.271 (0.173 to 0.369) < .001 
    4 y after donation 695 0.288 (0.164 to 0.412) < .001 
From before apheresis to after apheresis     
    Day 5 2316 −3.674 (−4.043 to −3.305) < .001 
    Day 6 1560 −9.725 (−9.980 to −9.470) < .001 
Change in platelets, from baseline, ×109/L     
    Day 5 before apheresis 2317 −10.01 (−11.32 to −8.693) < .001 
    1 mo after donation 1992 −6.169 (−7.823 to −4.515) < .001 
    1 y after donation 1640 1.084 (−0.652 to 2.819) .22 
    2 y after donation 1314 2.276 (0.190 to 4.361) .033 
    3 y after donation 1120 1.610 (−0.604 to 3.824) .15 
    4 y after donation 695 −0.135 (−3.051 to 2.78) .93 
From before apheresis to after apheresis     
    Day 5 2311 −92.28 (−94.07 to −90.49) < .001 
    Day 6 1557 −53.38 (−54.60 to −52.17) < .001 
Change in hemoglobin, from baseline, g/L     
    Day 5 before apheresis 2311 −2.02 (−2.31 to −1.73) < .001 
    1 mo after donation 1992 −2.99 (−3.31 to −2.67) < .001 
    1 y after donation 1637 −0.56 (−0.97 to −0.14) .009 
    2 y after donation 1315 −0.28 (−0.77 to 0.22) .28 
    3 y after donation 1121 −0.09 (−0.63 to 0.45) .74 
    4 y after donation 694 0.50 (−0.23 to 1.23) .18 
From before apheresis to after apheresis     
    Day 5 2291 −11.69 (−11.94 to −11.44) < .001 
    Day 6 1536 −10.41 (−10.73 to −10.10) < .001 

P values were from paired t test.

Median follow-up, 37 months; range, 2 days to 88 months.

WBC indicates white blood cell; PBSC, peripheral blood stem cell; NMDP, National Marrow Donor Program; and CI, confidence interval.

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