Clinical and laboratory data for 123 hepatitis C virus (HCV) patients with or without mixed cryoglobulinemia (MC)
| . | HCV, n = 66 . | MC-HCV, n = 57 . | P . |
|---|---|---|---|
| Age, y | 55.6 ± 24.3 | 58.8 ± 25.2 | ns |
| Sex (male/female), n | 43/23 | 22/35 | .003 |
| Histology, n | ns | ||
| Chronic hepatitis | 52 | 48 | |
| Cirrhosis | 14 | 9 | |
| ALT (× ULN) | 3.42 ± 1.7 | 3.11 ± 1.2 | ns |
| Viral titer, IU/mL × 106 | 2.5 ± 3.2 | 1.87 ± 1.64 | ns |
| HCV genotype, n (%) | ns | ||
| 1 | 39 (59%) | 32 (56%) | |
| 2 | 14 (21%) | 17 (30%) | |
| 3 | 9 (14%) | 6 (11%) | |
| 4 | 4 (6%) | 2 (3%) | |
| Cryocrit (%) | 0 | 6.9 ± 5.8 | < .001 |
| C3, mL/dL* | 114.3 ± 62.6 | 129.7 ± 58.2 | ns |
| C4, mL/dL† | 88.6 ± 48.7 | 13.5 ± 11.6 | < .001 |
| Rheumatoid factor, IU/mL‡ | 12.3 ± 7.2 | 427.5 ± 1190.4 | .005 |
| BAFF serum levels, ng/mL | 1.49 ± 0.21 | 3.22 ± 1.12 | < .001 |
| BAFF promoter genotype, % | |||
| T/T | 8 | 34 | < .001 |
| C/T | 48 | 46 | ns |
| C/C | 44 | 20 | .004 |
| Presence of T allele | 56 | 80 | .004 |
| . | HCV, n = 66 . | MC-HCV, n = 57 . | P . |
|---|---|---|---|
| Age, y | 55.6 ± 24.3 | 58.8 ± 25.2 | ns |
| Sex (male/female), n | 43/23 | 22/35 | .003 |
| Histology, n | ns | ||
| Chronic hepatitis | 52 | 48 | |
| Cirrhosis | 14 | 9 | |
| ALT (× ULN) | 3.42 ± 1.7 | 3.11 ± 1.2 | ns |
| Viral titer, IU/mL × 106 | 2.5 ± 3.2 | 1.87 ± 1.64 | ns |
| HCV genotype, n (%) | ns | ||
| 1 | 39 (59%) | 32 (56%) | |
| 2 | 14 (21%) | 17 (30%) | |
| 3 | 9 (14%) | 6 (11%) | |
| 4 | 4 (6%) | 2 (3%) | |
| Cryocrit (%) | 0 | 6.9 ± 5.8 | < .001 |
| C3, mL/dL* | 114.3 ± 62.6 | 129.7 ± 58.2 | ns |
| C4, mL/dL† | 88.6 ± 48.7 | 13.5 ± 11.6 | < .001 |
| Rheumatoid factor, IU/mL‡ | 12.3 ± 7.2 | 427.5 ± 1190.4 | .005 |
| BAFF serum levels, ng/mL | 1.49 ± 0.21 | 3.22 ± 1.12 | < .001 |
| BAFF promoter genotype, % | |||
| T/T | 8 | 34 | < .001 |
| C/T | 48 | 46 | ns |
| C/C | 44 | 20 | .004 |
| Presence of T allele | 56 | 80 | .004 |
Results are presented as means plus or minus SD except where otherwise noted.
ALT indicates alanine aminotransferase; ULN, upper limit of normal; and ns, not significant.
Complement C3 normal values range from 83 to 177 mL/dL.
Complement C4 normal values range from 20 to 150 mL/dL.
Rheumatoid factor normal values are < 25 UL/mL.