Table 2

Five-year survival, PFS and probabilities of CCyR, loss of CCyR, and continuing CCyR according to ELN failure criteria at 3, 6, 12, and 18 months, and suboptimal response criteria at 6, 12, and 18 months for the patients “nonfailure”

NSurvival, %PFS, %Probability of CCyR, %Probability of loss of CCyR, %
Failure at 3 mo  P = .0003 P = .002 P = .0003 NA 
    Yes 60.2 (CI, 40.2-79.8) 56.2 (CI, 37.1-73.6) NA 
    No 216 93.2 (CI, 86.7-96.7) 84.6 (CI, 77.8-89.6) 80.1 (CI, 70.0-82.9) 13.5 (CI, 8.7-20.4) 
Failure at 6 mo  P = .02 P = .009 P < .0001 P = .009 
    Yes 37 81.8 (CI, 70.2-89.6) 73.4 (CI, 64.9-80.4) 18.9 (CI, 12.3-27.9) 65.7 (CI, 41.3-83.9) 
    No 182 95.5 (CI, 89.8-98.1) 87.1 (CI, 81.4-91.2) 91.2 (CI, 87.8-93.7) 12.9 (CI, 8.1-19.9) 
Failure at 12 mo  P = .02 P = .002 P < .0001 P < .0001 
    Yes 50 87.1 (CI, 81.7-91.1) 76.0 (CI, 65.1-84.3) 26.7 (CI, 19.7-35.2) 51.0 (CI, 34.3-67.5) 
    No 165 95.1 (CI, 91.3-97.3) 90.0 (CI, 85.4-93.3) 94.1 (CI, 91.8-95.8) 10.3 (CI, 5.8-17.7) 
Failure at 18 mo  P = .03 P = .001 P < .0001 P = .001 
    Yes 66 87.8 (CI, 74.2-94.7) 76.4 (CI, 67.8-83.3) 31.8 (CI, 24.6-40.0) 27.2 (CI, 20.1-35.6) 
    No 131 98.5 (CI, 95.0-99.6) 97.1 (CI, 92.5-98.9) 100 9.6 (CI, 6.8-13.5) 
Suboptimal at 6 mo  P = .5 P = .05 P < .0001 P = .5 
    Yes 28 91.7 (CI, 68.6-98.2) 61.5 (CI, 33.4-83.6) 64.0 (CI, 55.9-71.4) 11.1 (CI, 4.6-24.5) 
    No 154 96.0 (CI, 90.0-98.5) 91.4 (CI, 83.6-95.7) 97.2 (CI, 94.5-98.6) 13.1 (CI, 10.4-16.3) 
Suboptimal at 12 mo  P = .02 P = .015 P < .0001 P = .4 
    Yes 45 85.4 (CI, 73.1-92.6) 73.4 (CI, 55.8-85.8) 77.8 (CI, 71.4-83.1) 3.0 (CI, 0.2-29.1) 
    No 120 98.4 (CI, 95.0-99.5) 96.1 (CI, 90.0-98.5) 100 10.2 (CI, 8.4-12.3) 
Suboptimal at 18 mo  P = .36 P = .48 — P = .008 
    Yes 91 98.3 (CI, 70.7-99.9) 97.2 (CI, 90.1-99.3) — 24.6 (CI, 19.2-30.9) 
    No 40 100 97.4 (CI, 90.0-99.4) — 
NSurvival, %PFS, %Probability of CCyR, %Probability of loss of CCyR, %
Failure at 3 mo  P = .0003 P = .002 P = .0003 NA 
    Yes 60.2 (CI, 40.2-79.8) 56.2 (CI, 37.1-73.6) NA 
    No 216 93.2 (CI, 86.7-96.7) 84.6 (CI, 77.8-89.6) 80.1 (CI, 70.0-82.9) 13.5 (CI, 8.7-20.4) 
Failure at 6 mo  P = .02 P = .009 P < .0001 P = .009 
    Yes 37 81.8 (CI, 70.2-89.6) 73.4 (CI, 64.9-80.4) 18.9 (CI, 12.3-27.9) 65.7 (CI, 41.3-83.9) 
    No 182 95.5 (CI, 89.8-98.1) 87.1 (CI, 81.4-91.2) 91.2 (CI, 87.8-93.7) 12.9 (CI, 8.1-19.9) 
Failure at 12 mo  P = .02 P = .002 P < .0001 P < .0001 
    Yes 50 87.1 (CI, 81.7-91.1) 76.0 (CI, 65.1-84.3) 26.7 (CI, 19.7-35.2) 51.0 (CI, 34.3-67.5) 
    No 165 95.1 (CI, 91.3-97.3) 90.0 (CI, 85.4-93.3) 94.1 (CI, 91.8-95.8) 10.3 (CI, 5.8-17.7) 
Failure at 18 mo  P = .03 P = .001 P < .0001 P = .001 
    Yes 66 87.8 (CI, 74.2-94.7) 76.4 (CI, 67.8-83.3) 31.8 (CI, 24.6-40.0) 27.2 (CI, 20.1-35.6) 
    No 131 98.5 (CI, 95.0-99.6) 97.1 (CI, 92.5-98.9) 100 9.6 (CI, 6.8-13.5) 
Suboptimal at 6 mo  P = .5 P = .05 P < .0001 P = .5 
    Yes 28 91.7 (CI, 68.6-98.2) 61.5 (CI, 33.4-83.6) 64.0 (CI, 55.9-71.4) 11.1 (CI, 4.6-24.5) 
    No 154 96.0 (CI, 90.0-98.5) 91.4 (CI, 83.6-95.7) 97.2 (CI, 94.5-98.6) 13.1 (CI, 10.4-16.3) 
Suboptimal at 12 mo  P = .02 P = .015 P < .0001 P = .4 
    Yes 45 85.4 (CI, 73.1-92.6) 73.4 (CI, 55.8-85.8) 77.8 (CI, 71.4-83.1) 3.0 (CI, 0.2-29.1) 
    No 120 98.4 (CI, 95.0-99.5) 96.1 (CI, 90.0-98.5) 100 10.2 (CI, 8.4-12.3) 
Suboptimal at 18 mo  P = .36 P = .48 — P = .008 
    Yes 91 98.3 (CI, 70.7-99.9) 97.2 (CI, 90.1-99.3) — 24.6 (CI, 19.2-30.9) 
    No 40 100 97.4 (CI, 90.0-99.4) — 

NA indicates not applicable.