Five-year survival, PFS and probabilities of CCyR, loss of CCyR, and continuing CCyR according to ELN failure criteria at 3, 6, 12, and 18 months, and suboptimal response criteria at 6, 12, and 18 months for the patients “nonfailure”
. | N . | Survival, % . | PFS, % . | Probability of CCyR, % . | Probability of loss of CCyR, % . |
---|---|---|---|---|---|
Failure at 3 mo | P = .0003 | P = .002 | P = .0003 | NA | |
Yes | 8 | 60.2 (CI, 40.2-79.8) | 56.2 (CI, 37.1-73.6) | 0 | NA |
No | 216 | 93.2 (CI, 86.7-96.7) | 84.6 (CI, 77.8-89.6) | 80.1 (CI, 70.0-82.9) | 13.5 (CI, 8.7-20.4) |
Failure at 6 mo | P = .02 | P = .009 | P < .0001 | P = .009 | |
Yes | 37 | 81.8 (CI, 70.2-89.6) | 73.4 (CI, 64.9-80.4) | 18.9 (CI, 12.3-27.9) | 65.7 (CI, 41.3-83.9) |
No | 182 | 95.5 (CI, 89.8-98.1) | 87.1 (CI, 81.4-91.2) | 91.2 (CI, 87.8-93.7) | 12.9 (CI, 8.1-19.9) |
Failure at 12 mo | P = .02 | P = .002 | P < .0001 | P < .0001 | |
Yes | 50 | 87.1 (CI, 81.7-91.1) | 76.0 (CI, 65.1-84.3) | 26.7 (CI, 19.7-35.2) | 51.0 (CI, 34.3-67.5) |
No | 165 | 95.1 (CI, 91.3-97.3) | 90.0 (CI, 85.4-93.3) | 94.1 (CI, 91.8-95.8) | 10.3 (CI, 5.8-17.7) |
Failure at 18 mo | P = .03 | P = .001 | P < .0001 | P = .001 | |
Yes | 66 | 87.8 (CI, 74.2-94.7) | 76.4 (CI, 67.8-83.3) | 31.8 (CI, 24.6-40.0) | 27.2 (CI, 20.1-35.6) |
No | 131 | 98.5 (CI, 95.0-99.6) | 97.1 (CI, 92.5-98.9) | 100 | 9.6 (CI, 6.8-13.5) |
Suboptimal at 6 mo | P = .5 | P = .05 | P < .0001 | P = .5 | |
Yes | 28 | 91.7 (CI, 68.6-98.2) | 61.5 (CI, 33.4-83.6) | 64.0 (CI, 55.9-71.4) | 11.1 (CI, 4.6-24.5) |
No | 154 | 96.0 (CI, 90.0-98.5) | 91.4 (CI, 83.6-95.7) | 97.2 (CI, 94.5-98.6) | 13.1 (CI, 10.4-16.3) |
Suboptimal at 12 mo | P = .02 | P = .015 | P < .0001 | P = .4 | |
Yes | 45 | 85.4 (CI, 73.1-92.6) | 73.4 (CI, 55.8-85.8) | 77.8 (CI, 71.4-83.1) | 3.0 (CI, 0.2-29.1) |
No | 120 | 98.4 (CI, 95.0-99.5) | 96.1 (CI, 90.0-98.5) | 100 | 10.2 (CI, 8.4-12.3) |
Suboptimal at 18 mo | P = .36 | P = .48 | — | P = .008 | |
Yes | 91 | 98.3 (CI, 70.7-99.9) | 97.2 (CI, 90.1-99.3) | — | 24.6 (CI, 19.2-30.9) |
No | 40 | 100 | 97.4 (CI, 90.0-99.4) | — | 0 |
. | N . | Survival, % . | PFS, % . | Probability of CCyR, % . | Probability of loss of CCyR, % . |
---|---|---|---|---|---|
Failure at 3 mo | P = .0003 | P = .002 | P = .0003 | NA | |
Yes | 8 | 60.2 (CI, 40.2-79.8) | 56.2 (CI, 37.1-73.6) | 0 | NA |
No | 216 | 93.2 (CI, 86.7-96.7) | 84.6 (CI, 77.8-89.6) | 80.1 (CI, 70.0-82.9) | 13.5 (CI, 8.7-20.4) |
Failure at 6 mo | P = .02 | P = .009 | P < .0001 | P = .009 | |
Yes | 37 | 81.8 (CI, 70.2-89.6) | 73.4 (CI, 64.9-80.4) | 18.9 (CI, 12.3-27.9) | 65.7 (CI, 41.3-83.9) |
No | 182 | 95.5 (CI, 89.8-98.1) | 87.1 (CI, 81.4-91.2) | 91.2 (CI, 87.8-93.7) | 12.9 (CI, 8.1-19.9) |
Failure at 12 mo | P = .02 | P = .002 | P < .0001 | P < .0001 | |
Yes | 50 | 87.1 (CI, 81.7-91.1) | 76.0 (CI, 65.1-84.3) | 26.7 (CI, 19.7-35.2) | 51.0 (CI, 34.3-67.5) |
No | 165 | 95.1 (CI, 91.3-97.3) | 90.0 (CI, 85.4-93.3) | 94.1 (CI, 91.8-95.8) | 10.3 (CI, 5.8-17.7) |
Failure at 18 mo | P = .03 | P = .001 | P < .0001 | P = .001 | |
Yes | 66 | 87.8 (CI, 74.2-94.7) | 76.4 (CI, 67.8-83.3) | 31.8 (CI, 24.6-40.0) | 27.2 (CI, 20.1-35.6) |
No | 131 | 98.5 (CI, 95.0-99.6) | 97.1 (CI, 92.5-98.9) | 100 | 9.6 (CI, 6.8-13.5) |
Suboptimal at 6 mo | P = .5 | P = .05 | P < .0001 | P = .5 | |
Yes | 28 | 91.7 (CI, 68.6-98.2) | 61.5 (CI, 33.4-83.6) | 64.0 (CI, 55.9-71.4) | 11.1 (CI, 4.6-24.5) |
No | 154 | 96.0 (CI, 90.0-98.5) | 91.4 (CI, 83.6-95.7) | 97.2 (CI, 94.5-98.6) | 13.1 (CI, 10.4-16.3) |
Suboptimal at 12 mo | P = .02 | P = .015 | P < .0001 | P = .4 | |
Yes | 45 | 85.4 (CI, 73.1-92.6) | 73.4 (CI, 55.8-85.8) | 77.8 (CI, 71.4-83.1) | 3.0 (CI, 0.2-29.1) |
No | 120 | 98.4 (CI, 95.0-99.5) | 96.1 (CI, 90.0-98.5) | 100 | 10.2 (CI, 8.4-12.3) |
Suboptimal at 18 mo | P = .36 | P = .48 | — | P = .008 | |
Yes | 91 | 98.3 (CI, 70.7-99.9) | 97.2 (CI, 90.1-99.3) | — | 24.6 (CI, 19.2-30.9) |
No | 40 | 100 | 97.4 (CI, 90.0-99.4) | — | 0 |
NA indicates not applicable.