Relative mRNA expression in 50 individuals according to DHFR genotypes and haplotype pairs
| Genotypes and haplotype pairs . | N . | mRNA . | SE . | P . |
|---|---|---|---|---|
| C−1610G/T | ||||
| CC | 22 | 0.15 | 0.02 | .04 |
| CG | 12 | 0.07 | 0.01 | — |
| CT | 1 | 0.07 | — | — |
| GG | 4 | 0.08 | 0.02 | — |
| GT | 10 | 0.09 | 0.02 | — |
| TT | 1 | 0.11 | — | — |
| C−680A | ||||
| CC | 24 | 0.10 | 0.02 | .7 |
| CA | 21 | 0.12 | 0.01 | — |
| AA | 5 | 0.13 | 0.04 | — |
| A−317G | ||||
| GG | 8 | 0.12 | 0.03 | >.9 |
| AG | 30 | 0.11 | 0.01 | — |
| AA | 12 | 0.11 | 0.03 | — |
| 19-bp indel | ||||
| Ins/ins | 13 | 0.11 | 0.04 | .9 |
| Ins/del | 28 | 0.11 | 0.01 | — |
| Del/del | 9 | 0.12 | 0.02 | — |
| Haplotypes | ||||
| *1*1 | 4 | 0.20 | 0.08 | .3 |
| *1*3 | 11 | 0.14 | 0.02 | — |
| *1*5 | 5 | 0.06 | 0.01 | — |
| *2*3 | 1 | 0.07 | — | — |
| *3*3 | 5 | 0.13 | 0.04 | — |
| *3*4 | 2 | 0.09 | 0.02 | — |
| *3*5 | 7 | 0.09 | 0.03 | — |
| *4*4 | 1 | 0.10 | — | — |
| *4*5 | 10 | 0.09 | 0.02 | — |
| *5*5 | 4 | 0.08 | 0.01 | — |
| Genotypes and haplotype pairs . | N . | mRNA . | SE . | P . |
|---|---|---|---|---|
| C−1610G/T | ||||
| CC | 22 | 0.15 | 0.02 | .04 |
| CG | 12 | 0.07 | 0.01 | — |
| CT | 1 | 0.07 | — | — |
| GG | 4 | 0.08 | 0.02 | — |
| GT | 10 | 0.09 | 0.02 | — |
| TT | 1 | 0.11 | — | — |
| C−680A | ||||
| CC | 24 | 0.10 | 0.02 | .7 |
| CA | 21 | 0.12 | 0.01 | — |
| AA | 5 | 0.13 | 0.04 | — |
| A−317G | ||||
| GG | 8 | 0.12 | 0.03 | >.9 |
| AG | 30 | 0.11 | 0.01 | — |
| AA | 12 | 0.11 | 0.03 | — |
| 19-bp indel | ||||
| Ins/ins | 13 | 0.11 | 0.04 | .9 |
| Ins/del | 28 | 0.11 | 0.01 | — |
| Del/del | 9 | 0.12 | 0.02 | — |
| Haplotypes | ||||
| *1*1 | 4 | 0.20 | 0.08 | .3 |
| *1*3 | 11 | 0.14 | 0.02 | — |
| *1*5 | 5 | 0.06 | 0.01 | — |
| *2*3 | 1 | 0.07 | — | — |
| *3*3 | 5 | 0.13 | 0.04 | — |
| *3*4 | 2 | 0.09 | 0.02 | — |
| *3*5 | 7 | 0.09 | 0.03 | — |
| *4*4 | 1 | 0.10 | — | — |
| *4*5 | 10 | 0.09 | 0.02 | — |
| *5*5 | 4 | 0.08 | 0.01 | — |
P is obtained by ANOVA and reflects differences across all indicated genotypes at a given locus or across all haplotype pairs. Respective differences in mRNA expression at the −1610 locus (CC−1610 individuals vs others) and between individuals with and without *1*1 and *1*3 haplotype pairs are given in Figure 3B.
SE indicates standard error of mean; —, not calculated due to only one individual with given genotype/haplotype.