Knockdown of Hbz gene expression significantly decreased tumor size in vivo
| Animal inoculum . | Tumor size, mm . | Average . | Standard . | Tumor volume . | Average . | Standard . | Tumor weight, g . | Average . | Standard . |
|---|---|---|---|---|---|---|---|---|---|
| SLB-1 | |||||||||
| M1 | 16 × 21 | 268.8 | 1.82 | ||||||
| M2 | 16 × 18 | 227.0 | 1.56 | ||||||
| M3 | 16 × 21 | 268.8 | 2.00 | ||||||
| M4 | 21 × 22 | 363.1 | 1.75 | ||||||
| M5 | − | 355.5 | 74.5 | − | 281.9 | 57.6 | − | 1.79 | .18 |
| SLB-V4 | |||||||||
| M6 | 12 × 14 | 132.7 | 1.04 | ||||||
| M7 | 14 × 15 | 165.2 | 0.93 | ||||||
| M8 | − | − | − | ||||||
| M9 | 12 × 14 | 132.7 | 0.94 | ||||||
| M10 | 12 × 13 | 175.5* | 88.9 | 122.7 | 138.3* | 18.5 | 1.12 | 1.01* | .09 |
| SLB-V5 | |||||||||
| M11 | 18 × 19 | 268.8 | 1.42 | ||||||
| M12 | 15 × 21 | 254.5 | 1.72 | ||||||
| M13 | 15 × 17 | 201.1 | 1.29 | ||||||
| M14 | − | − | − | ||||||
| M15 | 16 × 18.5 | 302.0 | 44.5 | 233.7 | 239.5 | 29.4 | 1.58 | 1.50 | .19 |
| Jurkat, M16-M20 | N/A | N/A | N/A |
| Animal inoculum . | Tumor size, mm . | Average . | Standard . | Tumor volume . | Average . | Standard . | Tumor weight, g . | Average . | Standard . |
|---|---|---|---|---|---|---|---|---|---|
| SLB-1 | |||||||||
| M1 | 16 × 21 | 268.8 | 1.82 | ||||||
| M2 | 16 × 18 | 227.0 | 1.56 | ||||||
| M3 | 16 × 21 | 268.8 | 2.00 | ||||||
| M4 | 21 × 22 | 363.1 | 1.75 | ||||||
| M5 | − | 355.5 | 74.5 | − | 281.9 | 57.6 | − | 1.79 | .18 |
| SLB-V4 | |||||||||
| M6 | 12 × 14 | 132.7 | 1.04 | ||||||
| M7 | 14 × 15 | 165.2 | 0.93 | ||||||
| M8 | − | − | − | ||||||
| M9 | 12 × 14 | 132.7 | 0.94 | ||||||
| M10 | 12 × 13 | 175.5* | 88.9 | 122.7 | 138.3* | 18.5 | 1.12 | 1.01* | .09 |
| SLB-V5 | |||||||||
| M11 | 18 × 19 | 268.8 | 1.42 | ||||||
| M12 | 15 × 21 | 254.5 | 1.72 | ||||||
| M13 | 15 × 17 | 201.1 | 1.29 | ||||||
| M14 | − | − | − | ||||||
| M15 | 16 × 18.5 | 302.0 | 44.5 | 233.7 | 239.5 | 29.4 | 1.58 | 1.50 | .19 |
| Jurkat, M16-M20 | N/A | N/A | N/A |
Mouse tumor size was measured in millimeters (length × width) with the average and standard deviation indicated. Mouse tumor volumes were calculated by the formula 3.142 × radius2 . Mouse solid tumor weights (in grams) were taken at day of sacrifice. M5 and M8 were sacrificed on day 17 due to necrosis and are not included in the final averaged numbers (−). M14 died on day 22 due to complications from peritoneal injection and also was not included in the final average numbers (−). N/A; not applicable, because no tumor mass at day 22 in any of the Jurkat cell–inoculated animals.
indicates statistically significant difference from SLB-1– and SLB-V5–inoculated mice.