Table 1 Biologic and clinical... | American Society of Hematology

Table 1

Biologic and clinical characteristics of the patients

Patient no.	Age, y	Sex	Rai stage*	WBC count/mm³	Lymphocytes, %	V_H mutational status†	ZAP70 expression‡
1	51	M	0	33 300	87.1	Mutated	−
2	64	F	0	49 600	83.6	Mutated	+
3	46	F	0	25 000	74.4	Mutated	−
4	58	F	0	37 500	84.0	Unmutated	+
5	67	M	0	18 600	82.8	Mutated	ND
6	64	F	I	68 900	85.5	Mutated	−
7	72	F	I	16 600	92.4	Mutated	−
8	68	M	I	29 600	81.2	Mutated	−
9	44	F	I	50 200	89.5	Mutated	−
10	70	F	I	15 200	76 3	Mutated	+
11	74	M	I	17 700	68.6	Unmutated	+
12	75	F	I	14 200	60.0	Unmutated	+
13	63	M	I	28 800	84.0	ND	−
14	56	M	I	77 000	82.5	Mutated	+
15	49	F	I	37 200	83.4	Unmutated	+
16	60	M	I	11 500	77.6	Mutated	+
17	69	M	I	18 500	81.5	Unmutated	+
18	74	M	II	28 000	85.0	Mutated	−
19	59	M	II	156 200	75.9	ND	−
20	65	M	II	27 680	79.7	Mutated	−
21	65	M	II	142 000	80.2	Unmutated	ND
22	63	M	II	33 000	85.1	Unmutated	+
23	66	M	III	29 700	88.6	Mutated	−
24	60	M	III	39 400	74.0	Unmutated	+
25	60	M	III	73 640	88.7	Mutated	−
26	60	M	III	33 500	79.5	Mutated	+
27	68	M	III	128 800	96.4	Unmutated	+
28	84	M	IV	160 500	76.1	Unmutated	+
29	80	F	IV	27 300	84.6	Mutated	+
30	77	F	IV	46 700	88.8	Mutated	−
31	77	M	IV	120 600	79.1	Unmutated	+
32	74	F	IV	31 700	85.6	Unmutated	+
33	85	M	IV	36 800	91.6	Mutated	−
34	63	M	IV	106 100	85.6	Mutated	−
35	80	M	IV	41 300	87.8	Unmutated	+
36	82	M	IV	150 800	76.0	Mutated	−
37	58	M	IV	32 800	89.0	ND	−
38	60	M	IV	87 600	94.4	Unmutated	+
39	33	F	IV	21 700	81.6	Unmutated	+
40	64	M	IV	51 700	82.1	Mutated	ND

Patient no.	Age, y	Sex	Rai stage*	WBC count/mm³	Lymphocytes, %	V_H mutational status†	ZAP70 expression‡
1	51	M	0	33 300	87.1	Mutated	−
2	64	F	0	49 600	83.6	Mutated	+
3	46	F	0	25 000	74.4	Mutated	−
4	58	F	0	37 500	84.0	Unmutated	+
5	67	M	0	18 600	82.8	Mutated	ND
6	64	F	I	68 900	85.5	Mutated	−
7	72	F	I	16 600	92.4	Mutated	−
8	68	M	I	29 600	81.2	Mutated	−
9	44	F	I	50 200	89.5	Mutated	−
10	70	F	I	15 200	76 3	Mutated	+
11	74	M	I	17 700	68.6	Unmutated	+
12	75	F	I	14 200	60.0	Unmutated	+
13	63	M	I	28 800	84.0	ND	−
14	56	M	I	77 000	82.5	Mutated	+
15	49	F	I	37 200	83.4	Unmutated	+
16	60	M	I	11 500	77.6	Mutated	+
17	69	M	I	18 500	81.5	Unmutated	+
18	74	M	II	28 000	85.0	Mutated	−
19	59	M	II	156 200	75.9	ND	−
20	65	M	II	27 680	79.7	Mutated	−
21	65	M	II	142 000	80.2	Unmutated	ND
22	63	M	II	33 000	85.1	Unmutated	+
23	66	M	III	29 700	88.6	Mutated	−
24	60	M	III	39 400	74.0	Unmutated	+
25	60	M	III	73 640	88.7	Mutated	−
26	60	M	III	33 500	79.5	Mutated	+
27	68	M	III	128 800	96.4	Unmutated	+
28	84	M	IV	160 500	76.1	Unmutated	+
29	80	F	IV	27 300	84.6	Mutated	+
30	77	F	IV	46 700	88.8	Mutated	−
31	77	M	IV	120 600	79.1	Unmutated	+
32	74	F	IV	31 700	85.6	Unmutated	+
33	85	M	IV	36 800	91.6	Mutated	−
34	63	M	IV	106 100	85.6	Mutated	−
35	80	M	IV	41 300	87.8	Unmutated	+
36	82	M	IV	150 800	76.0	Mutated	−
37	58	M	IV	32 800	89.0	ND	−
38	60	M	IV	87 600	94.4	Unmutated	+
39	33	F	IV	21 700	81.6	Unmutated	+
40	64	M	IV	51 700	82.1	Mutated	ND

ND indicates not determined; −, negative; and +, positive.

Staging system developed by Rai et al.³¹

Mutated was defined as having a frequency of mutations greater than 2% from germline V_H sequence.

As determined by immunoblot analysis on purified B cells (purity at least 98%).