Characteristics of the 416 patients
Sex ratio, M/F, no. | 225/191 |
Median age (range), y | 72 (65-85) |
Performance status, no. patients | |
0 | 109 |
1 | 193 |
2 | 102 |
3 | 12 |
Median WBC count (range), × 109/L | 5.3 (0.1-420) |
AML morphology, no. patients | |
de novo AML | 353 |
RAEB-T | 26 |
FAB-M1/2 | 173 |
FAB-M4/5 | 112 |
FAB-M0/6/7 | 122 |
Unclassified | 20 |
post-MDS AML | 63 |
RAEB-T | 16 |
Other | 47 |
Karyotype, no. patients | |
Not done | 27 |
Failure | 50 |
High risk | 49 |
Monosomy 7 | 7 |
Abnormalities of chromosome 5 and 7 | 6 |
3q26 abnormalities | 4 |
Complex, 5 abnormalities or more | 32 |
Standard risk | 290 |
t(8;21) | 6 |
inv(16)/t(16;16) | 6 |
Normal | 168 |
Isolated trisomy 8 | 17 |
del(5q) | 13 |
del(7q) | 9 |
11q23 abnormalities | 6 |
Complex, 3 or 4 abnormalities | 8 |
Other various abnormalities | 57 |
Sex ratio, M/F, no. | 225/191 |
Median age (range), y | 72 (65-85) |
Performance status, no. patients | |
0 | 109 |
1 | 193 |
2 | 102 |
3 | 12 |
Median WBC count (range), × 109/L | 5.3 (0.1-420) |
AML morphology, no. patients | |
de novo AML | 353 |
RAEB-T | 26 |
FAB-M1/2 | 173 |
FAB-M4/5 | 112 |
FAB-M0/6/7 | 122 |
Unclassified | 20 |
post-MDS AML | 63 |
RAEB-T | 16 |
Other | 47 |
Karyotype, no. patients | |
Not done | 27 |
Failure | 50 |
High risk | 49 |
Monosomy 7 | 7 |
Abnormalities of chromosome 5 and 7 | 6 |
3q26 abnormalities | 4 |
Complex, 5 abnormalities or more | 32 |
Standard risk | 290 |
t(8;21) | 6 |
inv(16)/t(16;16) | 6 |
Normal | 168 |
Isolated trisomy 8 | 17 |
del(5q) | 13 |
del(7q) | 9 |
11q23 abnormalities | 6 |
Complex, 3 or 4 abnormalities | 8 |
Other various abnormalities | 57 |
WBC indicates white blood cell count; FAB, French-American-British classification; RAEB-T, refractory anemia with excess of blast in transformation.