Patient and molecular data on C-MYB rearranged T-ALL cases
| Case no. . | Sex . | Age, y . | Oncogenic transcripts* . | CDKN2A/p16/ARF deletion† . | NOTCH1 mutations‡ . |
|---|---|---|---|---|---|
| t(6;7) TCRB-MYB cases | |||||
| TL92 | M | 1.1 | Neg | + | HD-N |
| TL93 | F | 1.3 | Neg | + | wt |
| TL34 | M | 1.8 | Neg | − | wt |
| T142 | F | 2.5 | Neg | + | PEST |
| UPN5846 | F | 2.9 | Neg | + | HD-N |
| TL33 | F | 10 | Neg | + | PEST |
| MYB cases | |||||
| TL38 | M | 5 | MLL-ENL | − | wt |
| TL29 | F | 6 | SIL-TAL | + | HD-N |
| TL77 | F | 8 | Neg | + | wt |
| TL61 | M | 10 | TLX3 | + | PEST |
| TL66 | M | 16 | TLX3 | + | PEST |
| TL40 | M | 17 | CALM-AF10 | + | HD-N + PEST |
| TL76 | M | 24 | Neg | − | HD-N |
| TL49 | M | 40 | TLX1 | + | HD-C |
| TL59 | M | 45 | TLX1, NUP214-ABL1 | + | wt |
| TL01 | F | 50 | Neg | + | wt |
| TL63 | F | 52 | TLX3 | + | HD-N + PEST |
| CCRF-CEM | na | na | SIL-TAL | + | HD-N |
| MOLT4 | na | na | Neg | + | HD-N + PEST |
| Case no. . | Sex . | Age, y . | Oncogenic transcripts* . | CDKN2A/p16/ARF deletion† . | NOTCH1 mutations‡ . |
|---|---|---|---|---|---|
| t(6;7) TCRB-MYB cases | |||||
| TL92 | M | 1.1 | Neg | + | HD-N |
| TL93 | F | 1.3 | Neg | + | wt |
| TL34 | M | 1.8 | Neg | − | wt |
| T142 | F | 2.5 | Neg | + | PEST |
| UPN5846 | F | 2.9 | Neg | + | HD-N |
| TL33 | F | 10 | Neg | + | PEST |
| MYB cases | |||||
| TL38 | M | 5 | MLL-ENL | − | wt |
| TL29 | F | 6 | SIL-TAL | + | HD-N |
| TL77 | F | 8 | Neg | + | wt |
| TL61 | M | 10 | TLX3 | + | PEST |
| TL66 | M | 16 | TLX3 | + | PEST |
| TL40 | M | 17 | CALM-AF10 | + | HD-N + PEST |
| TL76 | M | 24 | Neg | − | HD-N |
| TL49 | M | 40 | TLX1 | + | HD-C |
| TL59 | M | 45 | TLX1, NUP214-ABL1 | + | wt |
| TL01 | F | 50 | Neg | + | wt |
| TL63 | F | 52 | TLX3 | + | HD-N + PEST |
| CCRF-CEM | na | na | SIL-TAL | + | HD-N |
| MOLT4 | na | na | Neg | + | HD-N + PEST |
Cases are ordered by increasing age in the TCRB-MYB and MYBdup cases.
M indicates male; F, female; +, deletion detected; −, no deletion detected; wt, wild type; and na, not applicable.
Oncogenic transcripts searched for were as follows: SIL-TAL, TLX1, TLX3, HOXA, CALM-AF10, MLL, and NUP214-ABL1 fusions transcripts.
CDKN2A/p16/ARF locus analysis.
NOTCH1 mutations were searched in exons 26, 27, and 34, encoding N-terminal part of heterodimerization domain (HD-N), C-terminal part of heterodimerization domain (HD-C), and PEST domain, respectively. Immunophenotypic data of the 6 TCRB-MYB cases are shown in Figure S6.