Characteristics of the 83 maB-NHLs analyzed in the present study (detailed information is shown in Table S1)
| Molecular diagnosis . | Age, y: median (min-max) . | Sex, F/M . | Morphology: BL/aBL/DLBCL/agNHL . | t(MYC): yes/no . | IGH/BCL2: yes/no . | Imbalances*: median (min-max) . |
|---|---|---|---|---|---|---|
| Total, n = 83 | 60 (2-90) | 32/51 (39%/61%) | 5/12/60/6 (6%/14%/72%/7%) | 26/57 (31%/69%) | 10/73 (12%/88%) | 7 (0-25) |
| mBL, n = 18 | 13 (2-63) | 6/12 (33%/67%) | 5/10/2/1 (28%/56%/11%/6%) | 18/0 (100%/0%) | 0/18 (0%/100%) | 2 (0-17) |
| Non-mBL, n = 49 | 66 (18-88) | 19/30 (39%/61%) | 0/0/46/3 (0%/0%/94%/6%) | 2/47 (4%/96%) | 6/43 (12%/88%) | 9 (0-22) |
| ABC, n = 29 | 67 (41-88) | 10/19 (34%/66%) | 0/0/28/1 (0%/0%/97%/3%) | 1/28 (3%/97%) | 0/29 (0%/100%) | 9.5 (3-22) |
| GCB, n = 20 | 62 (18-85) | 9/11 (45%/55%) | 0/0/18/2 (0%/0%/90%/10%) | 1/19 (5%/95%) | 6/14 (30%/70%) | 7.5 (0-16) |
| Intermediate, n = 16 | 56 (4-90) | 7/9 (44%/56%) | 0/2/12/2 (0%/13%/75%/13%) | 6/10 (38%/63%) | 4/12 (25%/75%) | 8.5 (0-25) |
| Molecular diagnosis . | Age, y: median (min-max) . | Sex, F/M . | Morphology: BL/aBL/DLBCL/agNHL . | t(MYC): yes/no . | IGH/BCL2: yes/no . | Imbalances*: median (min-max) . |
|---|---|---|---|---|---|---|
| Total, n = 83 | 60 (2-90) | 32/51 (39%/61%) | 5/12/60/6 (6%/14%/72%/7%) | 26/57 (31%/69%) | 10/73 (12%/88%) | 7 (0-25) |
| mBL, n = 18 | 13 (2-63) | 6/12 (33%/67%) | 5/10/2/1 (28%/56%/11%/6%) | 18/0 (100%/0%) | 0/18 (0%/100%) | 2 (0-17) |
| Non-mBL, n = 49 | 66 (18-88) | 19/30 (39%/61%) | 0/0/46/3 (0%/0%/94%/6%) | 2/47 (4%/96%) | 6/43 (12%/88%) | 9 (0-22) |
| ABC, n = 29 | 67 (41-88) | 10/19 (34%/66%) | 0/0/28/1 (0%/0%/97%/3%) | 1/28 (3%/97%) | 0/29 (0%/100%) | 9.5 (3-22) |
| GCB, n = 20 | 62 (18-85) | 9/11 (45%/55%) | 0/0/18/2 (0%/0%/90%/10%) | 1/19 (5%/95%) | 6/14 (30%/70%) | 7.5 (0-16) |
| Intermediate, n = 16 | 56 (4-90) | 7/9 (44%/56%) | 0/2/12/2 (0%/13%/75%/13%) | 6/10 (38%/63%) | 4/12 (25%/75%) | 8.5 (0-25) |
mBL indicates molecular Burkitt lymphoma; ABC, activated B cell; GCB, germinal center B cell; F, female; M, male; BL, Burkitt lymphoma; aBL, atypical BL; DLBCL, diffuse large B-cell lymphoma; agNHL, aggressive B-NHL unclassifiable; t(MYC), translocation affecting the MYC locus; and IGH/BCL2, fusion of the IGH and BCL2 loci as a result of a translocation t(14;18)(q32;q21).
Defined as number of chromosomal imbalances detected by array comparative genomic hybridization (CGH).17