2001 WHO criteria for prefibrotic stage primary myelofibrosis
| 2001 criteria for prefibrotic PMF . |
|---|
| Clinical findings |
| Spleen and liver |
| No or mild splenomegaly or hepatomegaly |
| Hematology (variable) |
| Mild anemia |
| Mild to moderate leukocytosis |
| Mild to marked thrombocytosis |
| Morphological findings |
| Blood |
| No or mild leukoerythroblastosis |
| No or mild red blood cell poikilocytosis |
| Few if any dacryocytes |
| Bone marrow |
| Hypercellularity |
| Neutrophilic proliferation |
| Megakaryocytic proliferation |
| Megakaryocytic atypia* |
| Minimal or absent reticulin fibrosis |
| 2001 criteria for prefibrotic PMF . |
|---|
| Clinical findings |
| Spleen and liver |
| No or mild splenomegaly or hepatomegaly |
| Hematology (variable) |
| Mild anemia |
| Mild to moderate leukocytosis |
| Mild to marked thrombocytosis |
| Morphological findings |
| Blood |
| No or mild leukoerythroblastosis |
| No or mild red blood cell poikilocytosis |
| Few if any dacryocytes |
| Bone marrow |
| Hypercellularity |
| Neutrophilic proliferation |
| Megakaryocytic proliferation |
| Megakaryocytic atypia* |
| Minimal or absent reticulin fibrosis |
Clustering of megakaryocytes, abnormally lobulated megakaryocytic nuclei, naked megakaryocytic nuclei.