Causes of death
| Reported main cause . | All patients, no. (%) . | Eligible for HSCT, no.* (%) . | Group 1: with related donor, no. (%) . | Group 2: without related donor . | Group 3: not eligible for HSCT, no. (%) . | |
|---|---|---|---|---|---|---|
| 2A: no transplantation in chronic phase, no. (%) . | 2B: MUD transplantation in chronic phase, no. (%) . | |||||
| No. dead/total | 318/621 | 154/356 | 61/135 | 61/122 | 30/97 | 164/265 |
| Blast crisis | 135 (42.5) | 50* (32.5) | 12 (19.7) | 35 (57.4) | 2 (6.7) | 85 (51.8) |
| Transplant related† | 83 (26.1) | 78 (50.7) | 39 (63.9) | 15 (24.6) | 24 (80.0) | 5 (3.1) |
| CML related other than blast crisis | 40 (12.6) | 10* (6.5) | 4 (6.6) | 4 (6.6) | 1 (3.3) | 30 (18.3) |
| Not directly CML related‡ | 56 (17.6) | 16 (10.4) | 6 (9.8) | 7 (11.5) | 3 (10.0) | 40 (24.4) |
| Unknown | 4 (1.3) | — | — | — | — | 4 (2.4) |
| Reported main cause . | All patients, no. (%) . | Eligible for HSCT, no.* (%) . | Group 1: with related donor, no. (%) . | Group 2: without related donor . | Group 3: not eligible for HSCT, no. (%) . | |
|---|---|---|---|---|---|---|
| 2A: no transplantation in chronic phase, no. (%) . | 2B: MUD transplantation in chronic phase, no. (%) . | |||||
| No. dead/total | 318/621 | 154/356 | 61/135 | 61/122 | 30/97 | 164/265 |
| Blast crisis | 135 (42.5) | 50* (32.5) | 12 (19.7) | 35 (57.4) | 2 (6.7) | 85 (51.8) |
| Transplant related† | 83 (26.1) | 78 (50.7) | 39 (63.9) | 15 (24.6) | 24 (80.0) | 5 (3.1) |
| CML related other than blast crisis | 40 (12.6) | 10* (6.5) | 4 (6.6) | 4 (6.6) | 1 (3.3) | 30 (18.3) |
| Not directly CML related‡ | 56 (17.6) | 16 (10.4) | 6 (9.8) | 7 (11.5) | 3 (10.0) | 40 (24.4) |
| Unknown | 4 (1.3) | — | — | — | — | 4 (2.4) |
— indicates that no patient was classified as eligible for HSCT (columns 2 to 5).
For 2 patients, availability of a related donor remained unknown. Thus, the patients could not be classified into groups 1, 2A, or 2B.
Underwent transplantation in accelerated or blastic phase: group 1 (n = 4), group 2a (n = 15), group 2b (n = 0), group 3 (n = 1), all patients (n = 20).
Not directly CML-related causes of death were organ failure (heart, kidney, liver, lung; n = 20), thromboembolism (n = 9), other neoplasia (n = 9), infection (n = 8), suicide (n = 4), other (accident, hemorrhage [2], aortic aneurysm, seizures, Creutzfeld-Jakob; n = 6).