Administration schedule for rapid infusion rituximab in combination with corticosteroid-containing chemotherapy
| Premedications |
| · Diphenhydramine 50 mg orally |
| · Acetaminophen 375 mg orally |
| · Daily corticosteroid dose according to chemotherapy protocol |
| Cycle 1 |
| Rituximab 375 mg/m2 intravenously infused according to product monograph |
| Cycles 2–8 |
| Rituximab 375 mg/m2 intravenously in 250 mL NS |
| · 20% of dose infused over 30 minutes |
| · Remaining 80% of dose infused over 60 minutes, total infusion time of 90 minutes |
| Premedications |
| · Diphenhydramine 50 mg orally |
| · Acetaminophen 375 mg orally |
| · Daily corticosteroid dose according to chemotherapy protocol |
| Cycle 1 |
| Rituximab 375 mg/m2 intravenously infused according to product monograph |
| Cycles 2–8 |
| Rituximab 375 mg/m2 intravenously in 250 mL NS |
| · 20% of dose infused over 30 minutes |
| · Remaining 80% of dose infused over 60 minutes, total infusion time of 90 minutes |