Levels of systemic inflammatory mediators
| . | Baseline . | +DIC . | P . | ||
|---|---|---|---|---|---|
| Vehicle . | P4pal-10 . | Vehicle . | P4pal-10 . | ||
| IL6, ng/mL | nd | nd | 22.6 ± 6 | 7.8 ± 2.8* | <.05 |
| MCP-1, ng/mL | 48.5 ± 9 | 34.6 ± 15 | 57.1 ± 9 | 24.6 ± 6.8* | <.05 |
| IFNγ, pg/mL | nd | nd | 698 ± 145 | 327 ± 65* | <.05 |
| TNFα, pg/mL | nd | nd | 435 ± 83 | 255 ± 67 | .05 |
| . | Baseline . | +DIC . | P . | ||
|---|---|---|---|---|---|
| Vehicle . | P4pal-10 . | Vehicle . | P4pal-10 . | ||
| IL6, ng/mL | nd | nd | 22.6 ± 6 | 7.8 ± 2.8* | <.05 |
| MCP-1, ng/mL | 48.5 ± 9 | 34.6 ± 15 | 57.1 ± 9 | 24.6 ± 6.8* | <.05 |
| IFNγ, pg/mL | nd | nd | 698 ± 145 | 327 ± 65* | <.05 |
| TNFα, pg/mL | nd | nd | 435 ± 83 | 255 ± 67 | .05 |
IL-6, MCP-1, IFNγ, and TNFα levels were determined in mouse plasma before (baseline) and after the induction of the Shwartzman reaction (+DIC) in mice subjected to P1pal-10 (0.5 mg/kg) or vehicle control. Data are means (± SEM).
nd indicates nondetectable, below detection limit.
P < .05.