Locus-specific impact of DNA CN on gene expression for candidate genes within select MCRs
| Cytoband . | Locus description . | Genes* . | . | . | . | . |
|---|---|---|---|---|---|---|
| Gains | ||||||
| 1q21.1 | MCL1 | OTUD7B | PIAS3 | BCL9 | NOTCH2NL | |
| 2p15 | Amplified in PMBL35 | ACTR2 | PELI1 | SLC1A4 | REL | BCL11A |
| 3q21.3 | CNBP | GATA2 | MCM2 | PIK3R4 | ||
| 3q27.3 | BCL6 | RFC4 | ST6GAL1 | TBCCD1 | ||
| 11q13.1 | BBS1 | ANKRD13D | RELA | ZNHIT2 | CCND1 | |
| 12q15 | Adult GCB35 | FRS2 | RAB3IP | IFNG | MDM1 | MDM2 |
| 16p11.2 | Novel in pediatric DLBCL | FUS | MAZ | BCL7C | CD19 | NFATC2IP |
| 19q13.2 | Adult ABC35 | AKT2 | LYPD4 | PAK4 | CD79A | NFKBIB |
| Losses | ||||||
| 2q13 | SEPT10 | BCL2L11 | ||||
| 4p14 | Novel in pediatric DLBCL | APBB2 | RHOH | TLR1/6/10 | ||
| 6q21 | Adult ABC35 | ATG5 | AIM1 | FOXO3 | LIN28B | PRDM1 |
| 6q23.3 | HBS1L | BCLAF1 | PERP | IFNGR1 | TNFAIP3 | |
| 12q24.31 | RHOF | BCL7A | DIABLO | |||
| 16p11.2 | TAOK2 | NFATC2IP | BCL7C | CD19 | TP53TG3 | |
| 19p13.3 | RFX2 | EBI3 | TNFAIP8L1 | TNFSF14 | TNFSF9 | |
| 19q13.32 | Novel in pediatric DLBCL | BAX | BBC3 | BCL3 | IRF2BP1 |
| Cytoband . | Locus description . | Genes* . | . | . | . | . |
|---|---|---|---|---|---|---|
| Gains | ||||||
| 1q21.1 | MCL1 | OTUD7B | PIAS3 | BCL9 | NOTCH2NL | |
| 2p15 | Amplified in PMBL35 | ACTR2 | PELI1 | SLC1A4 | REL | BCL11A |
| 3q21.3 | CNBP | GATA2 | MCM2 | PIK3R4 | ||
| 3q27.3 | BCL6 | RFC4 | ST6GAL1 | TBCCD1 | ||
| 11q13.1 | BBS1 | ANKRD13D | RELA | ZNHIT2 | CCND1 | |
| 12q15 | Adult GCB35 | FRS2 | RAB3IP | IFNG | MDM1 | MDM2 |
| 16p11.2 | Novel in pediatric DLBCL | FUS | MAZ | BCL7C | CD19 | NFATC2IP |
| 19q13.2 | Adult ABC35 | AKT2 | LYPD4 | PAK4 | CD79A | NFKBIB |
| Losses | ||||||
| 2q13 | SEPT10 | BCL2L11 | ||||
| 4p14 | Novel in pediatric DLBCL | APBB2 | RHOH | TLR1/6/10 | ||
| 6q21 | Adult ABC35 | ATG5 | AIM1 | FOXO3 | LIN28B | PRDM1 |
| 6q23.3 | HBS1L | BCLAF1 | PERP | IFNGR1 | TNFAIP3 | |
| 12q24.31 | RHOF | BCL7A | DIABLO | |||
| 16p11.2 | TAOK2 | NFATC2IP | BCL7C | CD19 | TP53TG3 | |
| 19p13.3 | RFX2 | EBI3 | TNFAIP8L1 | TNFSF14 | TNFSF9 | |
| 19q13.32 | Novel in pediatric DLBCL | BAX | BBC3 | BCL3 | IRF2BP1 |
Genes highlighted in bold showed a significant correlation between gene expression and gene CN. Locus description annotates MCR in the pediatric cases that were either novel or that have been previously reported to be enriched in specific DLBCL subtypes.