Differential pathway and gene set enrichment in adult and pediatric tumors
| Broad GeneSets . | No. of genes . | P (Goeman global test) . |
|---|---|---|
| Enrichment in Adult mGCB relative to Ped mGCB | ||
| BASSO_GERMINAL_CENTER_CD40_UP | 225 | .023 |
| TH1 TH2 PATHWAY | 28 | .009 |
| CELL_CYCLE_CHECKPOINT_II | 21 | .022 |
| CTLA4 PATHWAY | 41 | .009 |
| TARTE_BCELL | 71 | .024 |
| Enrichment in Adult mBL relative to Ped mBL | ||
| APOPTOSIS_KEGG | 118 | .0003 |
| BRENTANI_DEATH | 176 | .002 |
| APOPTOSIS_GENMAPP | 99 | .001 |
| APOPTOSIS | 168 | .001 |
| CASPASE PATHWAY | 54 | .0005 |
| SA_FAS_SIGNALING | 27 | .002 |
| DEATH PATHWAY | 86 | .002 |
| BAD PATHWAY | 60 | .004 |
| P38 MAPK PATHWAY | 104 | .009 |
| ST_P38_MAPK_PATHWAY | 99 | .02 |
| IL10 PATHWAY | 31 | .001 |
| IL18 PATHWAY | 10 | .001 |
| RAS PATHWAY | 53 | .016 |
| AKT PATHWAY | 32 | .026 |
| ST_JAK_STAT_PATHWAY | 23 | .003 |
| KIM_TH_CELLS_UP | 115 | .007 |
| ST_TUMOR_NECROSIS_FACTOR_PATHWAY | 67 | .009 |
| G1_TO_S_CELL_CYCLE_REACTOME | 142 | .008 |
| SIG_BCR_SIGNALING_PATHWAY | 139 | .005 |
| BCR PATHWAY | 98 | .019 |
| SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | 97 | .003 |
| BASSO_GERMINAL_CENTER_CD40_UP | 225 | .004 |
| Enrichment in Pediatric mBL relative to Adult mBL | ||
| INFLAMMATORY_RESPONSE_PATHWAY | 70 | .002 |
| MYC_TARGETS | 109 | .0006 |
| Broad GeneSets . | No. of genes . | P (Goeman global test) . |
|---|---|---|
| Enrichment in Adult mGCB relative to Ped mGCB | ||
| BASSO_GERMINAL_CENTER_CD40_UP | 225 | .023 |
| TH1 TH2 PATHWAY | 28 | .009 |
| CELL_CYCLE_CHECKPOINT_II | 21 | .022 |
| CTLA4 PATHWAY | 41 | .009 |
| TARTE_BCELL | 71 | .024 |
| Enrichment in Adult mBL relative to Ped mBL | ||
| APOPTOSIS_KEGG | 118 | .0003 |
| BRENTANI_DEATH | 176 | .002 |
| APOPTOSIS_GENMAPP | 99 | .001 |
| APOPTOSIS | 168 | .001 |
| CASPASE PATHWAY | 54 | .0005 |
| SA_FAS_SIGNALING | 27 | .002 |
| DEATH PATHWAY | 86 | .002 |
| BAD PATHWAY | 60 | .004 |
| P38 MAPK PATHWAY | 104 | .009 |
| ST_P38_MAPK_PATHWAY | 99 | .02 |
| IL10 PATHWAY | 31 | .001 |
| IL18 PATHWAY | 10 | .001 |
| RAS PATHWAY | 53 | .016 |
| AKT PATHWAY | 32 | .026 |
| ST_JAK_STAT_PATHWAY | 23 | .003 |
| KIM_TH_CELLS_UP | 115 | .007 |
| ST_TUMOR_NECROSIS_FACTOR_PATHWAY | 67 | .009 |
| G1_TO_S_CELL_CYCLE_REACTOME | 142 | .008 |
| SIG_BCR_SIGNALING_PATHWAY | 139 | .005 |
| BCR PATHWAY | 98 | .019 |
| SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | 97 | .003 |
| BASSO_GERMINAL_CENTER_CD40_UP | 225 | .004 |
| Enrichment in Pediatric mBL relative to Adult mBL | ||
| INFLAMMATORY_RESPONSE_PATHWAY | 70 | .002 |
| MYC_TARGETS | 109 | .0006 |