MV analysis for T-cell reconstitution 2 to 5 years after non-MSD HCT
| Variable and categories . | N (N event)* . | HR estimate (95% CI)† . | P . | Overall P‡ . |
|---|---|---|---|---|
| Conditioning | ||||
| No/IS (baseline) | 174 (115) | 1.00 | <.001 | |
| RIC/MAC | 80 (74) | 9.77 (3.47-27.54) | <.001 | |
| Genotype | ||||
| IL2RG/JAK3 (baseline) | 114 (94) | 1.00 | .002 | |
| IL7R, CD3 (any), CD45 | 22 (14) | 0.43 (0.16-1.19) | .104 | |
| ADA | 11 (8) | 0.59 (0.14-2.51) | .472 | |
| DCLRE1C | 10 (5) | 0.15 (0.03-0.67) | .013 | |
| RAG | 15 (8) | 0.04 (0.01-0.24) | <.001 | |
| Other/unknown | 82 (60) | 0.32 (0.15-0.68) | .003 | |
| Stratum | ||||
| A (baseline) | 232 (170) | 1.00 | .169 | |
| B | 22 (19) | 3.57 (0.58-21.87) | .169 |
| Variable and categories . | N (N event)* . | HR estimate (95% CI)† . | P . | Overall P‡ . |
|---|---|---|---|---|
| Conditioning | ||||
| No/IS (baseline) | 174 (115) | 1.00 | <.001 | |
| RIC/MAC | 80 (74) | 9.77 (3.47-27.54) | <.001 | |
| Genotype | ||||
| IL2RG/JAK3 (baseline) | 114 (94) | 1.00 | .002 | |
| IL7R, CD3 (any), CD45 | 22 (14) | 0.43 (0.16-1.19) | .104 | |
| ADA | 11 (8) | 0.59 (0.14-2.51) | .472 | |
| DCLRE1C | 10 (5) | 0.15 (0.03-0.67) | .013 | |
| RAG | 15 (8) | 0.04 (0.01-0.24) | <.001 | |
| Other/unknown | 82 (60) | 0.32 (0.15-0.68) | .003 | |
| Stratum | ||||
| A (baseline) | 232 (170) | 1.00 | .169 | |
| B | 22 (19) | 3.57 (0.58-21.87) | .169 |
For each “variable,” the categories are compared with the “baseline” reference group.
The P values displayed for the individual categories of a variable help to assess the relative evidence of effect among the individual categories, relative to each other, but cannot be interpreted as common P values. The “HR” characterizes the ratio in instantaneous chance of T-cell reconstitution during 2 to 5 y after HCT, relative to the reference group. Other statistically significant pairwise comparisons include ADA vs RAG: HR, 16.17 (95% CI, 1.65-158.82), P = .017; IL7R/CD3/CD45 vs RAG: HR, 11.88 (95% CI, 1.55-91.22), P = .017; Other/unknown vs RAG: HR, 8.82 (95% CI, 1.42-54.68), P = .019.
“N” is the number of subjects in the category of the variable; the “N event” is T-cell reconstitution during 2 to 5 y after HCT; T-cell reconstitution is defined as meeting ≥2 of the following 3 criteria: PHA proliferative response > 50% of the lower limit of the reference range for healthy controls, CD3+ cell count > 1000 cells per cubic millimeter, or CD4+ cell count > 500 cells per cubic millimeter.
The “HR estimate” is for the event of T-cell reconstitution.
“Overall P” provides the overall significance of the variable in the model.