MV analysis of independent factors for survival in non-MSD HCT
| Variable and categories . | N (N event)* . | HR estimate (95% CI)† . | P . | Overall P‡ . |
|---|---|---|---|---|
| Age at HCT/infection | ||||
| <3.5 m/no infection (baseline) | 87 (12) | 1.00 | <.001 | |
| <3.5 m/infected/active | 26 (5) | 1.02 (0.35-3.02) | .966 | |
| <3.5 m/infected/resolved | 17 (1) | 0.40 (0.05-3.13) | .386 | |
| ≥3.5 m/infected/active | 240 (110) | 3.55 (1.91-6.62) | <.001 | |
| ≥3.5 m/infected/resolved | 138 (42) | 2.14 (1.11-4.14) | .023 | |
| ≥3.5 m/no infection | 43 (10) | 1.37 (0.58-3.24) | .470 | |
| Infected/unknown | 20 (7) | 2.32 (0.89-6.06) | .087 | |
| Failure to thrive | ||||
| No (baseline) | 370 (100) | 1.00 | .046 | |
| Yes | 201 (87) | 1.37 (1.01-1.86) | .046 | |
| Genotype | ||||
| IL2RG/JAK3 (baseline) | 198 (45) | 1.00 | <.001 | |
| ADA | 40 (15) | 2.04 (1.12-3.73) | .020 | |
| DCLRE1C | 18 (9) | 4.78 (2.02-11.33) | <.001 | |
| IL7R, CD3 (any), CD45 | 43 (11) | 1.22 (0.62-2.41) | .565 | |
| Other/unknown/ND | 234 (98) | 2.18 (1.51-3.15) | <.001 | |
| RAG | 38 (9) | 1.33 (0.61-2.86) | .472 | |
| Race/ethnicity | ||||
| White and non-Hispanic (baseline) | 272 (61) | 1.00 | <.001 | |
| American Indian/Alaska native | 25 (10) | 1.17 (0.53-2.59) | .690 | |
| Black or African American and non-Hispanic | 51 (28) | 3.23 (2.04-5.11) | <.001 | |
| Hispanic | 116 (40) | 1.75 (1.16-2.65) | .008 | |
| Unknown | 107 (48) | 2.27 (1.54-3.35) | <.001 | |
| Stratum | ||||
| A (baseline) | 503 (167) | 1.00 | .958 | |
| B | 68 (20) | 0.99 (0.60-1.63) | .958 |
| Variable and categories . | N (N event)* . | HR estimate (95% CI)† . | P . | Overall P‡ . |
|---|---|---|---|---|
| Age at HCT/infection | ||||
| <3.5 m/no infection (baseline) | 87 (12) | 1.00 | <.001 | |
| <3.5 m/infected/active | 26 (5) | 1.02 (0.35-3.02) | .966 | |
| <3.5 m/infected/resolved | 17 (1) | 0.40 (0.05-3.13) | .386 | |
| ≥3.5 m/infected/active | 240 (110) | 3.55 (1.91-6.62) | <.001 | |
| ≥3.5 m/infected/resolved | 138 (42) | 2.14 (1.11-4.14) | .023 | |
| ≥3.5 m/no infection | 43 (10) | 1.37 (0.58-3.24) | .470 | |
| Infected/unknown | 20 (7) | 2.32 (0.89-6.06) | .087 | |
| Failure to thrive | ||||
| No (baseline) | 370 (100) | 1.00 | .046 | |
| Yes | 201 (87) | 1.37 (1.01-1.86) | .046 | |
| Genotype | ||||
| IL2RG/JAK3 (baseline) | 198 (45) | 1.00 | <.001 | |
| ADA | 40 (15) | 2.04 (1.12-3.73) | .020 | |
| DCLRE1C | 18 (9) | 4.78 (2.02-11.33) | <.001 | |
| IL7R, CD3 (any), CD45 | 43 (11) | 1.22 (0.62-2.41) | .565 | |
| Other/unknown/ND | 234 (98) | 2.18 (1.51-3.15) | <.001 | |
| RAG | 38 (9) | 1.33 (0.61-2.86) | .472 | |
| Race/ethnicity | ||||
| White and non-Hispanic (baseline) | 272 (61) | 1.00 | <.001 | |
| American Indian/Alaska native | 25 (10) | 1.17 (0.53-2.59) | .690 | |
| Black or African American and non-Hispanic | 51 (28) | 3.23 (2.04-5.11) | <.001 | |
| Hispanic | 116 (40) | 1.75 (1.16-2.65) | .008 | |
| Unknown | 107 (48) | 2.27 (1.54-3.35) | <.001 | |
| Stratum | ||||
| A (baseline) | 503 (167) | 1.00 | .958 | |
| B | 68 (20) | 0.99 (0.60-1.63) | .958 |
For each variable, the categories are compared with the “baseline” reference group. The P values displayed for the individual categories of a variable help to assess the relative evidence of effect among the individual categories, relative to each other, but cannot be interpreted as common P values. The “HR” characterizes the ratio in instantaneous chance of death relative to the reference group. Other statistically significant pairwise comparisons include <3.5 months and active infection vs >3.5 months and active infection: HR, 0.29 (95% CI, 0.11-0.74), P = .009; >3.5 months and active infection vs >3.5 months and no infection: HR, 2.59 (95% CI, 1.34-5.00), P = .005; >3.5 months and active infection vs >3.5 months and resolved infection: HR, 1.66 (95% CI, 1.16-2.38), P = .006; <3.5 months and resolved infection vs >3.5 months and active infection: HR, 0.11 (95% CI, 0.02-0.82), P = .031; DCLRE1C vs IL7R-CD3-CD45: HR, 3.91 (95% CI, 1.43-10.74), P = .008; DCLRE1C vs RAG: HR, 3.60 (95% CI, 1.22-10.61), P = .020; American Indian/Alaska native vs black or African American/Non-Hispanic, HR, 0.36 (95% CI, 0.15-0.86), P = .021; and black or African American/non-Hispanic vs Hispanic: HR, 1.84 (95% CI, 1.11-3.05); P = .018.
ND, not done.
“N” is the number of subjects in the category of the variable; the “N event” is defined by death.
The “HR estimate” is for the event of death.
“Overall P” provides the overall significance of the variable in the model.