Distribution of donor type and conditioning regimen according to clinical presentation (stratum)
| . | Total (N = 662) . | Stratum A (typical SCID) (n = 581) . | Stratum B (leaky SCID/Omenn/RD) (n = 81) . | P . |
|---|---|---|---|---|
| Donor type | <.001 | |||
| MSD | 91 (14) | 78 (13) | 13 (16) | |
| MORD | 28 (4) | 26 (4) | 2 (2) | |
| MMRD | 413 (62) | 381 (66) | 32 (39) | |
| URD | 130 (20) | 96 (16) | 34 (42) | |
| Conditioning MSD | 91 | 78 | 13 | .002 |
| None | 54 (59) | 48 (62) | 6 (46) | |
| IS | 23 (25) | 22 (28) | 1 (8) | |
| RIC | 7 (8) | 5 (6) | 2 (15) | |
| MAC | 7 (8) | 3 (4) | 4 (31) | |
| Conditioning MORD | 28 | 26 | 2 | .799 |
| No CR | 19 (68) | 18 (69) | 1 (50) | |
| IS | 5 (18) | 4 (15) | 1 (50) | |
| RIC | 2 (7) | 2 (8) | 0 | |
| MAC | 1 (4) | 1 (4) | 0 | |
| Unknown CR | 1 (4) | 1 (4) | 0 | |
| Conditioning MMRD | 413 | 381 | 32 | .002 |
| No CR | 252 (61) | 240 (63) | 12 (38) | |
| IS | 52 (13) | 48 (13) | 4 (12) | |
| RIC | 20 (5) | 19 (5) | 1 (3) | |
| MAC | 87 (21) | 73 (19) | 14 (44) | |
| Unknown CR | 2 (0) | 1 (<1) | 1 (3) | |
| Conditioning URD | 130 | 96 | 34 | .092 |
| No CR | 11 (8) | 10 (10) | 1 (3) | |
| IS | 23 (18) | 21 (22) | 2 (6) | |
| RIC | 40 (31) | 29 (30) | 11 (32) | |
| MAC | 53 (41) | 34 (35) | 19 (56) | |
| Unknown CR | 3 (2) | 2 (2) | 1 (3) | |
| Conditioning, all donors | 662 | 581 | 81 | <.001 |
| No CR | 336 (51) | 316 (54) | 20 (25) | |
| IS | 103 (15) | 95 (16) | 8 (10) | |
| RIC | 69 (10) | 55 (9) | 14 (17) | |
| MAC | 148 (22) | 111 (19) | 37 (46) | |
| Unknown CR | 6 (1) | 4 (1) | 2 (2) |
| . | Total (N = 662) . | Stratum A (typical SCID) (n = 581) . | Stratum B (leaky SCID/Omenn/RD) (n = 81) . | P . |
|---|---|---|---|---|
| Donor type | <.001 | |||
| MSD | 91 (14) | 78 (13) | 13 (16) | |
| MORD | 28 (4) | 26 (4) | 2 (2) | |
| MMRD | 413 (62) | 381 (66) | 32 (39) | |
| URD | 130 (20) | 96 (16) | 34 (42) | |
| Conditioning MSD | 91 | 78 | 13 | .002 |
| None | 54 (59) | 48 (62) | 6 (46) | |
| IS | 23 (25) | 22 (28) | 1 (8) | |
| RIC | 7 (8) | 5 (6) | 2 (15) | |
| MAC | 7 (8) | 3 (4) | 4 (31) | |
| Conditioning MORD | 28 | 26 | 2 | .799 |
| No CR | 19 (68) | 18 (69) | 1 (50) | |
| IS | 5 (18) | 4 (15) | 1 (50) | |
| RIC | 2 (7) | 2 (8) | 0 | |
| MAC | 1 (4) | 1 (4) | 0 | |
| Unknown CR | 1 (4) | 1 (4) | 0 | |
| Conditioning MMRD | 413 | 381 | 32 | .002 |
| No CR | 252 (61) | 240 (63) | 12 (38) | |
| IS | 52 (13) | 48 (13) | 4 (12) | |
| RIC | 20 (5) | 19 (5) | 1 (3) | |
| MAC | 87 (21) | 73 (19) | 14 (44) | |
| Unknown CR | 2 (0) | 1 (<1) | 1 (3) | |
| Conditioning URD | 130 | 96 | 34 | .092 |
| No CR | 11 (8) | 10 (10) | 1 (3) | |
| IS | 23 (18) | 21 (22) | 2 (6) | |
| RIC | 40 (31) | 29 (30) | 11 (32) | |
| MAC | 53 (41) | 34 (35) | 19 (56) | |
| Unknown CR | 3 (2) | 2 (2) | 1 (3) | |
| Conditioning, all donors | 662 | 581 | 81 | <.001 |
| No CR | 336 (51) | 316 (54) | 20 (25) | |
| IS | 103 (15) | 95 (16) | 8 (10) | |
| RIC | 69 (10) | 55 (9) | 14 (17) | |
| MAC | 148 (22) | 111 (19) | 37 (46) | |
| Unknown CR | 6 (1) | 4 (1) | 2 (2) |
Data in first 3 columns are shown as n (%). Descriptive statistics and univariate analyses were performed by stratum, for strata A and B. Statistics of frequencies were calculated for categorical variables at each subgroup of donor type. χ2 tests were applied to evaluate the association.
CR, conditioning regimen; Omenn, Omenn syndrome; RD, reticular dysgenesis.