Table 5.

Chimerism and GVHD data for HLH patients with reactivations

IDDay of HLH reactivation*Type of HLH reactivationDay of grade II-IV aGVHD onset*Day of cGVHD onset*Pre/Post HLH reactivationDay unfractionated sample collected*Type of unfractionated sampleUnfractionated sample, % donorT-cell sample collected*Type of T-cell sampleT-cell sample, % donorMinimum recorded chimerism
% DonorDay of sampleSample type
139 Systemic 97 143 Pre
Post 
97
143 
Blood
Blood 
10
71 
97
143 
Blood
Blood 
84
170 Marrow 
15 314 Systemic No reported aGVHD No reported cGVHD Pre
Post 
181
315 
Blood
Marrow 
14
181
315 
Blood
Blood 
37
14 
318 Marrow 
20 61 Systemic No reported aGVHD 298 Pre
Post 

— 

— 

— 
39
53 
Blood
Blood 
56
61 
56 39 T-cell 
24 138
328 
CNS
CNS 
No reported aGVHD 155 Pre
Post
Post (2nd activation) 
96
186
333 
Blood
Blood
Blood 
100
98
90 
96
186
333 
Blood
Blood
Blood 
100
100
97 
90 27 T-cell 
28 88 Both 35 No reported cGVHD Pre
Post 
56
84 
Blood
Blood 
100
100 

— 

— 

— 
100 28 Marrow 
IDDay of HLH reactivation*Type of HLH reactivationDay of grade II-IV aGVHD onset*Day of cGVHD onset*Pre/Post HLH reactivationDay unfractionated sample collected*Type of unfractionated sampleUnfractionated sample, % donorT-cell sample collected*Type of T-cell sampleT-cell sample, % donorMinimum recorded chimerism
% DonorDay of sampleSample type
139 Systemic 97 143 Pre
Post 
97
143 
Blood
Blood 
10
71 
97
143 
Blood
Blood 
84
170 Marrow 
15 314 Systemic No reported aGVHD No reported cGVHD Pre
Post 
181
315 
Blood
Marrow 
14
181
315 
Blood
Blood 
37
14 
318 Marrow 
20 61 Systemic No reported aGVHD 298 Pre
Post 

— 

— 

— 
39
53 
Blood
Blood 
56
61 
56 39 T-cell 
24 138
328 
CNS
CNS 
No reported aGVHD 155 Pre
Post
Post (2nd activation) 
96
186
333 
Blood
Blood
Blood 
100
98
90 
96
186
333 
Blood
Blood
Blood 
100
100
97 
90 27 T-cell 
28 88 Both 35 No reported cGVHD Pre
Post 
56
84 
Blood
Blood 
100
100 

— 

— 

— 
100 28 Marrow 

Last available chimerism data from before HLH reactivation and chimerism reported on the HLH reactivation case report form.

*

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