List of the JAK1 and JAK3 mutations identified in GF-independent TS1 clones
| JAK1 . | JAK3 . | Number of TS1 clones (n = 50) . |
|---|---|---|
| V645A* | — | 1 |
| Y652H* | — | 16 |
| Y652D* | — | 1 |
| K847E | — | 4 |
| F958V | — | 1 |
| — | A572V* | 1 |
| — | L586S | 6 |
| — | R657H* | 2 |
| — | F666L | 1 |
| — | V674A* | 10 |
| — | Y824C* | 1 |
| — | T848A | 1 |
| S646P* | L586V | 1 |
| Y652H* | R657H* | 1 |
| Y652H* | Y904C | 1 |
| Y652H* | Y939C | 1 |
| F958V | Y824C* | 1 |
| JAK1 . | JAK3 . | Number of TS1 clones (n = 50) . |
|---|---|---|
| V645A* | — | 1 |
| Y652H* | — | 16 |
| Y652D* | — | 1 |
| K847E | — | 4 |
| F958V | — | 1 |
| — | A572V* | 1 |
| — | L586S | 6 |
| — | R657H* | 2 |
| — | F666L | 1 |
| — | V674A* | 10 |
| — | Y824C* | 1 |
| — | T848A | 1 |
| S646P* | L586V | 1 |
| Y652H* | R657H* | 1 |
| Y652H* | Y904C | 1 |
| Y652H* | Y939C | 1 |
| F958V | Y824C* | 1 |
The 16 different mutations occurring either separately or associated. For each combination, the absolute frequency is indicated for 50 characterized TS1 clones. All 14 affected amino acids are conserved in mouse and human JAK (amino acid numbers correspond to human sequence).
Described in human cancers.