Cell growth-inhibitory profile of FF-10101 and other FLT3 inhibitors
| 32D cell lines . | GI50, nM . | |||
|---|---|---|---|---|
| FF-10101 . | Quizartinib . | Crenolanib . | Midostaurin . | |
| FLT3-ITD | 1.9 | 2.0 | 32 | 32 |
| FLT3-ITD-D835Y | 0.81 | 89 | 44 | 16 |
| FLT3-ITD-Y842C | 3.5 | 66 | 12 | 35 |
| FLT3-ITD-Y842H | 5.3 | 92 | 11 | 35 |
| FLT3-ITD-F691L | 10 | 220 | 290 | 35 |
| FLT3-D835Y | 0.32 | 5.7 | 2.8 | 2.9 |
| FLT3-D835H | 1.1 | 4.1 | 16 | 8.7 |
| Parent/IL-3 | 2300 | 2000 | 1200 | 270 |
| 32D cell lines . | GI50, nM . | |||
|---|---|---|---|---|
| FF-10101 . | Quizartinib . | Crenolanib . | Midostaurin . | |
| FLT3-ITD | 1.9 | 2.0 | 32 | 32 |
| FLT3-ITD-D835Y | 0.81 | 89 | 44 | 16 |
| FLT3-ITD-Y842C | 3.5 | 66 | 12 | 35 |
| FLT3-ITD-Y842H | 5.3 | 92 | 11 | 35 |
| FLT3-ITD-F691L | 10 | 220 | 290 | 35 |
| FLT3-D835Y | 0.32 | 5.7 | 2.8 | 2.9 |
| FLT3-D835H | 1.1 | 4.1 | 16 | 8.7 |
| Parent/IL-3 | 2300 | 2000 | 1200 | 270 |
Mean GI50 values from 2 or more independent experiments are indicated in the table. 32D-transfectant cell lines were incubated with various concentrations of FLT3 inhibitors at 37°C for 2 d followed by determination of GI50 values.