Table 3

Multivariate Cox regression model of EFS

Variable*Univariate analysesMultivariate model 1Multivariate model 2
HR95% CIPHR95% CIP†HR95% CIP†
Age at diagnosis (continuous, years) 1.24 1.10-1.39 .001       
At diagnosis   .001       
 <13 1         
 ≥13 7.12 2.19-23.17        
Gender   .349       
 Female 1         
 Male 1.69         
Ethnicity   .160       
 Non-Hispanic 1         
 Hispanic 3.42 0.44-26.31        
Trisomy 21   .470       
 Absent 1         
 Present 1.82 0.40-8.20        
NCI/Rome risk   .001   .016   .010 
 Standard 1   1   1   
 High 7.77 1.72-35.07  5.60 1.14-27.34  5.96 1.25-28.32  
WBC (per μL), continuous 4.83 2.14-10.90 <.001       
 WBC (per μL)   .008       
 <50 000 1         
 ≥50 000 4.87 1.63-14.51        
Cytogenetics   .044       
 Neutral 1         
 Favorable 0.20 0.02-1.53        
 Unfavorable 6.90 0.80-59.75        
Obese   .061       
 No 1         
 Yes 2.95 0.99-8.80        
Weight category   .045   .012   .081 
 Lean 1   1   1   
 Overweight 3.78 0.84-16.91  7.70 1.37-43.12  5.65 1.17-27.30  
 Obese 4.31 1.22-15.29  6.65 1.40-31.63  2.57 0.70-9.36  
Weight change during induction   .011       
 Gain 1         
 Loss 4.57 1.26-16.63        
End-induction MRD (%), continuous —‡  <.001 —‡  <.001    
End-induction MRD   .006      .045 
 Negative 1      1   
 Positive 4.72 1.54-14.45     3.48 1.00-12.12  
Variable*Univariate analysesMultivariate model 1Multivariate model 2
HR95% CIPHR95% CIP†HR95% CIP†
Age at diagnosis (continuous, years) 1.24 1.10-1.39 .001       
At diagnosis   .001       
 <13 1         
 ≥13 7.12 2.19-23.17        
Gender   .349       
 Female 1         
 Male 1.69         
Ethnicity   .160       
 Non-Hispanic 1         
 Hispanic 3.42 0.44-26.31        
Trisomy 21   .470       
 Absent 1         
 Present 1.82 0.40-8.20        
NCI/Rome risk   .001   .016   .010 
 Standard 1   1   1   
 High 7.77 1.72-35.07  5.60 1.14-27.34  5.96 1.25-28.32  
WBC (per μL), continuous 4.83 2.14-10.90 <.001       
 WBC (per μL)   .008       
 <50 000 1         
 ≥50 000 4.87 1.63-14.51        
Cytogenetics   .044       
 Neutral 1         
 Favorable 0.20 0.02-1.53        
 Unfavorable 6.90 0.80-59.75        
Obese   .061       
 No 1         
 Yes 2.95 0.99-8.80        
Weight category   .045   .012   .081 
 Lean 1   1   1   
 Overweight 3.78 0.84-16.91  7.70 1.37-43.12  5.65 1.17-27.30  
 Obese 4.31 1.22-15.29  6.65 1.40-31.63  2.57 0.70-9.36  
Weight change during induction   .011       
 Gain 1         
 Loss 4.57 1.26-16.63        
End-induction MRD (%), continuous —‡  <.001 —‡  <.001    
End-induction MRD   .006      .045 
 Negative 1      1   
 Positive 4.72 1.54-14.45     3.48 1.00-12.12  
*

Only significant variables are depicted in the table.

†

Likelihood ratio P values.

‡

Regression coefficient for MRD as a log10(MRD% + 1) transformed continuous variable included in multivariate model 1.

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