Table 1 Demographic and disease... | American Society of Hematology

Table 1

Demographic and disease characteristics

Characteristic	All patients		Weight category at diagnosis						P*
	All patients		Lean		Overweight		Obese
	No.	%	No.	%	No.	%	No.	%
Total	198	100.0	127	64.1	30	15.2	41	20.7
BMI percentile at diagnosis
Mean ± SD	60.3% ± 33.3%
Range	<1%-99.9%
Gender									.042
Male	101	51.0	58	45.7	15	50.0	28	68.3
Female	97	49.0	69	54.3	15	50.0	13	31.7
Age, years†									.002
Mean ± SD	8.2 ± 5.4
Range	1.2-18.9
<13	144	72.7	99	78.0	24	80.0	21	51.2
≥13	54	27.3	28	22.0	6	20.0	20	48.8
Ethnicity									.001
Hispanic	157	79.3	94	74.0	22	73.3	41	100.0
Non-Hispanic	41	20.7	33	26.0	8	26.7	0	0.0
Trisomy 21									.009
Absent	179	90.4	118	92.9	29	96.7	32	78.0
Present	19	9.6	9	7.1	1	3.3	9	22.0
NCI/Rome risk									.098
Standard	111	56.1	75	59.1	19	63.3	17	41.5
High	87	43.9	52	40.9	11	36.7	24	58.5
Initial WBC count (per μL)									.536
Median ± SD	9.0 ± 67.86
Range	600-562 000
<50 000	162	81.8	102	80.3	24	80.0	36	87.8
≥50 000	36	18.2	25	19.7	6	20.0	5	12.2
CNS disease‡									.029
CNS1	175	88.4	114	89.8	30	100.0	31	75.6
CNS2	21	10.6	12	9.4	0	0.0	9	22.0
CNS3	2	1.0	1	0.8	0	0.0	1	2.4
Leukemia cytogenetics									.432
Neutral	133	67.2	80	63.0	20	66.7	33	80.5
Favorable	58	29.3	41	32.3	10	33.3	7	17.1
Unfavorable	6	3.0	5	3.9	0	0.0	1	2.4
Unavailable	1	0.5	1	0.8	0	0.0	0	0.0
End of induction morphology§									NA
M1	194	98.0	196	99.0	0	0.0	196	99.0
M2	3	1.5	2	1.0	0	0.0	1	0.5
M3	1*	0.5	0	0.0	0	0.0	1	0.5
MRD, %									.032
Range	0-30\|\|
<0.01	143	72.2	98	77.2	22	73.3	23	56.1
≥0.01	55	27.8	29	22.8	8	26.7	18	43.9

Characteristic	All patients		Weight category at diagnosis						P*
	All patients		Lean		Overweight		Obese
	No.	%	No.	%	No.	%	No.	%
Total	198	100.0	127	64.1	30	15.2	41	20.7
BMI percentile at diagnosis
Mean ± SD	60.3% ± 33.3%
Range	<1%-99.9%
Gender									.042
Male	101	51.0	58	45.7	15	50.0	28	68.3
Female	97	49.0	69	54.3	15	50.0	13	31.7
Age, years†									.002
Mean ± SD	8.2 ± 5.4
Range	1.2-18.9
<13	144	72.7	99	78.0	24	80.0	21	51.2
≥13	54	27.3	28	22.0	6	20.0	20	48.8
Ethnicity									.001
Hispanic	157	79.3	94	74.0	22	73.3	41	100.0
Non-Hispanic	41	20.7	33	26.0	8	26.7	0	0.0
Trisomy 21									.009
Absent	179	90.4	118	92.9	29	96.7	32	78.0
Present	19	9.6	9	7.1	1	3.3	9	22.0
NCI/Rome risk									.098
Standard	111	56.1	75	59.1	19	63.3	17	41.5
High	87	43.9	52	40.9	11	36.7	24	58.5
Initial WBC count (per μL)									.536
Median ± SD	9.0 ± 67.86
Range	600-562 000
<50 000	162	81.8	102	80.3	24	80.0	36	87.8
≥50 000	36	18.2	25	19.7	6	20.0	5	12.2
CNS disease‡									.029
CNS1	175	88.4	114	89.8	30	100.0	31	75.6
CNS2	21	10.6	12	9.4	0	0.0	9	22.0
CNS3	2	1.0	1	0.8	0	0.0	1	2.4
Leukemia cytogenetics									.432
Neutral	133	67.2	80	63.0	20	66.7	33	80.5
Favorable	58	29.3	41	32.3	10	33.3	7	17.1
Unfavorable	6	3.0	5	3.9	0	0.0	1	2.4
Unavailable	1	0.5	1	0.8	0	0.0	0	0.0
End of induction morphology§									NA
M1	194	98.0	196	99.0	0	0.0	196	99.0
M2	3	1.5	2	1.0	0	0.0	1	0.5
M3	1*	0.5	0	0.0	0	0.0	1	0.5
MRD, %									.032
Range	0-30\|\|
<0.01	143	72.2	98	77.2	22	73.3	23	56.1
≥0.01	55	27.8	29	22.8	8	26.7	18	43.9

Pearson’s χ² test for distribution of predictors across BMI weight category.

Additionally analyzed per Children’s Oncology Group “very-high-risk” age threshold.

CNS1, no WBCs or blasts; CNS2, <5 WBCs and blasts; CNS3, ≥5 WBCs and blasts.

M1, <5% blasts; M2, 5% to 25% blasts; M3, >25% blasts.

Same patient with M3 marrow and 30% residual leukemia by flow cytometry.

CNS, central nervous system; NA, not applicable; SD, standard deviation.