Univariate Cox PH analysis of predictors of VTE recurrence among Olmsted County residents with active cancer-related incident DVT or PE, 1966-2000
| Characteristic . | HR . | 95% CI . | P value . |
|---|---|---|---|
| Baseline characteristics | |||
| Patient age at incident VTE event | 0.99 | 0.98, 1.01 | .28 |
| Male sex | 0.89 | 0.63, 1.24 | .47 |
| Body mass index, kg/m2 | 1.00 | 0.97, 1.02 | .78 |
| Incident VTE event type* | 1.18 | 0.84, 1.65 | .35 |
| Incident VTE event year | 0.99 | 0.97, 1.01 | .16 |
| Hospitalization† | |||
| Hospitalization with surgery | 0.94 | 0.65, 1.37 | .76 |
| Hospitalization without surgery | 1.16 | 0.73, 1.84 | .53 |
| Nursing home confinement | 1.73 | 0.76, 3.94 | .19 |
| Congestive heart failure | 1.27 | 0.75, 2.15 | .38 |
| Neurological disease with leg paresis | 2.74 | 1.34, 5.62 | .006 |
| Neurosurgery | 2.83 | 1.32, 6.08 | .008 |
| Cancer location‡ | |||
| Pancreas, stage IV | 5.15 | 2.25, 11.81 | .0001 |
| Brain | 3.98 | 1.87, 8.47 | .0003 |
| Ovary | 3.06 | 1.51, 6.19 | .0019 |
| Lung | 2.70 | 1.64, 4.43 | <.0001 |
| Gastrointestinal (not colorectal) | 2.52 | 1.20, 5.29 | .015 |
| Myeloproliferative or myelodysplastic disorder | 2.33 | 1.08, 4.99 | .03 |
| Nonpancreas, stage IV | 2.32 | 1.46, 3.68 | .0003 |
| Stage III cancer, ALL or AML | 1.35 | 0.87, 2.08 | .18 |
| Metastases | |||
| Liver metastases | 1.98 | 1.18, 3.31 | .009 |
| Other metastases | 1.50 | 1.03, 2.17 | .03 |
| Multiple active cancers | 2.11 | 1.07, 4.17 | .03 |
| Time-dependent characteristics | |||
| Heparin | 1.99 | 1.04, 3.82 | .04 |
| Warfarin | 0.39 | 0.26, 0.60 | <.0001 |
| IVC filter | 1.50 | 0.83, 2.71 | .18 |
| Characteristic . | HR . | 95% CI . | P value . |
|---|---|---|---|
| Baseline characteristics | |||
| Patient age at incident VTE event | 0.99 | 0.98, 1.01 | .28 |
| Male sex | 0.89 | 0.63, 1.24 | .47 |
| Body mass index, kg/m2 | 1.00 | 0.97, 1.02 | .78 |
| Incident VTE event type* | 1.18 | 0.84, 1.65 | .35 |
| Incident VTE event year | 0.99 | 0.97, 1.01 | .16 |
| Hospitalization† | |||
| Hospitalization with surgery | 0.94 | 0.65, 1.37 | .76 |
| Hospitalization without surgery | 1.16 | 0.73, 1.84 | .53 |
| Nursing home confinement | 1.73 | 0.76, 3.94 | .19 |
| Congestive heart failure | 1.27 | 0.75, 2.15 | .38 |
| Neurological disease with leg paresis | 2.74 | 1.34, 5.62 | .006 |
| Neurosurgery | 2.83 | 1.32, 6.08 | .008 |
| Cancer location‡ | |||
| Pancreas, stage IV | 5.15 | 2.25, 11.81 | .0001 |
| Brain | 3.98 | 1.87, 8.47 | .0003 |
| Ovary | 3.06 | 1.51, 6.19 | .0019 |
| Lung | 2.70 | 1.64, 4.43 | <.0001 |
| Gastrointestinal (not colorectal) | 2.52 | 1.20, 5.29 | .015 |
| Myeloproliferative or myelodysplastic disorder | 2.33 | 1.08, 4.99 | .03 |
| Nonpancreas, stage IV | 2.32 | 1.46, 3.68 | .0003 |
| Stage III cancer, ALL or AML | 1.35 | 0.87, 2.08 | .18 |
| Metastases | |||
| Liver metastases | 1.98 | 1.18, 3.31 | .009 |
| Other metastases | 1.50 | 1.03, 2.17 | .03 |
| Multiple active cancers | 2.11 | 1.07, 4.17 | .03 |
| Time-dependent characteristics | |||
| Heparin | 1.99 | 1.04, 3.82 | .04 |
| Warfarin | 0.39 | 0.26, 0.60 | <.0001 |
| IVC filter | 1.50 | 0.83, 2.71 | .18 |
Patients were followed-up through December 31, 2005. For all variables, the referent group is without the risk factor, except where indicated.
PE ± DVT vs DVT alone.
Compared with nonhospitalized. Hospitalized includes VTE occurring within 92 days of hospitalization.
The comparison group included stage I/stage II cancers of the prostate, breast, other gynecologic, colon-rectal, kidney, bladder, other genitourinary, and other cancer, as well as lymphoma, chronic myelocytic leukemia, and multiple myeloma.