Clinical characteristics of GEP cohort of initial pediatric AML samples
| . | Original GEP cohort (n = 245) . | Additional cases (n = 32) . | Total (n = 277) . |
|---|---|---|---|
| Sex | |||
| Male | 137 (56) | 13 (45) | 150 |
| Female | 108 (44) | 16 (55) | 124 |
| Age, y, median (range) | 9.8 (0-18.8) | 3.0 (0.4-17.3) | |
| WBC × 109/L, median (range) | 41.3 (0.0-483) | 117.5 (1.8-475) | |
| FAB | |||
| M0 | 14 (6) | 3 (9) | 17 (6) |
| M1 | 25 (10) | 1 (3) | 26 (9) |
| M2 | 55 (22) | 1 (3) | 56 (20) |
| M3 | 20 (8) | 20 (7) | |
| M4 | 56 (23) | 8 (25) | 64 (23) |
| M5 | 53 (22) | 18 (56) | 71 (26) |
| M6 | 3 (1) | 3 (1) | |
| M7 | 8 (3) | 8 (3) | |
| Unknown | 11 (4) | 1 (3) | 12 (4) |
| Cytogenetics | |||
| MLL rearrangements | 53 (23) | 32 (100) | 85 (31) |
| t(9;11)(p22;q23) | 21 (9) | 12 (38) | 33 (12) |
| Other MLL rearrangements | 32 (13) | 20 (63) | 52 (19) |
| t(8;21) (q22;q22) | 28 (11) | 28 (10) | |
| inv(16)(q13q22) | 27 (11) | 27 (10) | |
| t(15;17)(q22;q21) | 18 (7) | 18 (6) | |
| Cytogenetically normal (CN)-AML | 41 (17) | 41 (15) | |
| AML-other/unknown | 78 (32) | 78 (28) | |
| Successful GEP | 245 | 14 | 259 |
| Successful RT-qPCR | 76 | 19 | 95 |
| . | Original GEP cohort (n = 245) . | Additional cases (n = 32) . | Total (n = 277) . |
|---|---|---|---|
| Sex | |||
| Male | 137 (56) | 13 (45) | 150 |
| Female | 108 (44) | 16 (55) | 124 |
| Age, y, median (range) | 9.8 (0-18.8) | 3.0 (0.4-17.3) | |
| WBC × 109/L, median (range) | 41.3 (0.0-483) | 117.5 (1.8-475) | |
| FAB | |||
| M0 | 14 (6) | 3 (9) | 17 (6) |
| M1 | 25 (10) | 1 (3) | 26 (9) |
| M2 | 55 (22) | 1 (3) | 56 (20) |
| M3 | 20 (8) | 20 (7) | |
| M4 | 56 (23) | 8 (25) | 64 (23) |
| M5 | 53 (22) | 18 (56) | 71 (26) |
| M6 | 3 (1) | 3 (1) | |
| M7 | 8 (3) | 8 (3) | |
| Unknown | 11 (4) | 1 (3) | 12 (4) |
| Cytogenetics | |||
| MLL rearrangements | 53 (23) | 32 (100) | 85 (31) |
| t(9;11)(p22;q23) | 21 (9) | 12 (38) | 33 (12) |
| Other MLL rearrangements | 32 (13) | 20 (63) | 52 (19) |
| t(8;21) (q22;q22) | 28 (11) | 28 (10) | |
| inv(16)(q13q22) | 27 (11) | 27 (10) | |
| t(15;17)(q22;q21) | 18 (7) | 18 (6) | |
| Cytogenetically normal (CN)-AML | 41 (17) | 41 (15) | |
| AML-other/unknown | 78 (32) | 78 (28) | |
| Successful GEP | 245 | 14 | 259 |
| Successful RT-qPCR | 76 | 19 | 95 |
Values reflect number of cases (%) unless otherwise specified.
AML indicates acute myeloid leukemia; FAB, French-American-British morphology classification; GEP, gene expression profiling array; MLL, mixed-lineage leukemia; RT-qPCR, quantitative real-time polymerase chain reaction; and WBC, white blood cell count.