Baseline characteristics according to cytogenetic abnormalities
| . | Standard-risk (n = 188) . | High-risk* (n = 44) . | P . |
|---|---|---|---|
| Age, y (range) | 72 (65-85) | 72 (66-83) | NS |
| Hemoglobin, g/dL, mean | 10.8 | 9.6 | NS |
| Calcium, mg/dL, mean | 9.6 | 9.5 | NS |
| Creatinine, mg/dL, mean | 1.02 | 1.0 | NS |
| B2-microglobulin, mg/L, mean | 3.8 | 5.2 | NS |
| PCs BM infiltration, %, mean | 38 | 44 | NS |
| S-phase of PCs, % | 1.5 | 1.5 | NS |
| ISS stage, % | |||
| I | 28 | 16 | |
| II | 42 | 41 | NS |
| III | 30 | 43 | |
| Induction regimen, % | |||
| VMP/VTP | 49/51 | 50/50 | NS |
| Maintenance regimen, % | |||
| VT/VP | 51/49 | 54/46 | NS |
| . | Standard-risk (n = 188) . | High-risk* (n = 44) . | P . |
|---|---|---|---|
| Age, y (range) | 72 (65-85) | 72 (66-83) | NS |
| Hemoglobin, g/dL, mean | 10.8 | 9.6 | NS |
| Calcium, mg/dL, mean | 9.6 | 9.5 | NS |
| Creatinine, mg/dL, mean | 1.02 | 1.0 | NS |
| B2-microglobulin, mg/L, mean | 3.8 | 5.2 | NS |
| PCs BM infiltration, %, mean | 38 | 44 | NS |
| S-phase of PCs, % | 1.5 | 1.5 | NS |
| ISS stage, % | |||
| I | 28 | 16 | |
| II | 42 | 41 | NS |
| III | 30 | 43 | |
| Induction regimen, % | |||
| VMP/VTP | 49/51 | 50/50 | NS |
| Maintenance regimen, % | |||
| VT/VP | 51/49 | 54/46 | NS |
ISS indicates International Staging System; and PCs, plasma cells.
Forty-four of these 232 patients qualified as high-risk (19%); 17 of them (7%) had t(4;14) ± del(13q), 21 patients (9%) had del(17p) ± del(13q), in 3 cases (1%) t(4;14) and del(17p) coexisted, and 3 additional patients (1%) had t(14;16). Only 1 patient had t(4;14) as single CA.