The effect of MA-TCK26D6 on standard coagulation parameters in plasma of thromboembolism-induced mice
| . | Plt (109/L) . | Fbg (g/L) . | aPTT (s) . | PT (s) . | FVII (%) . | FVIII (%) . |
|---|---|---|---|---|---|---|
| Baseline | 316 ± 39 | 1.35 ± 0.06 | 20 ± 2 | 12 ± 0 | 67 ± 9 | 41 ± 10 |
| MA-T30E5A2 | 39 ± 4* | NC | NC | NC | 61 ± 4 | 7 ± 1* |
| MA-TCK26D6 | 64 ± 9*† | NC | NC | NC | 66 ± 9 | 11 ± 5* |
| . | Plt (109/L) . | Fbg (g/L) . | aPTT (s) . | PT (s) . | FVII (%) . | FVIII (%) . |
|---|---|---|---|---|---|---|
| Baseline | 316 ± 39 | 1.35 ± 0.06 | 20 ± 2 | 12 ± 0 | 67 ± 9 | 41 ± 10 |
| MA-T30E5A2 | 39 ± 4* | NC | NC | NC | 61 ± 4 | 7 ± 1* |
| MA-TCK26D6 | 64 ± 9*† | NC | NC | NC | 66 ± 9 | 11 ± 5* |
Data are mean ± SD (n = 5). Baseline levels were obtained by saline injections. Mouse plasma was collected 15 minutes after thromboplastin or saline injections: 26 mg/kg MA-T30E5A2 or 26 mg/kg MA-TCK26D6 was administered before thromboplastin injection.
Plt indicates blood platelets; Fbg, mouse fibrinogen; aPTT, activated partial thromboplastin time; PT, prothrombin time; FVII and FVIII, coagulation factors VII and VIII, respectively; and NC, no coagulation.
Significantly different (P < .001) from baseline levels.
P < .01 vs MA-T30E5A2.