Table 2

Multivariable models examining QOL outcomes

Age
Mild vs moderate
Moderate vs severe
Mild vs severe
Estimate95% lower95% upperPEstimate95% lower95% upperPEstimate95% lower95% upperPEstimate95% lower95% upperP
PCS −0.11* −0.21* −0.004* .04* 2.41 −1.57 6.39 .23 3.20* 0.60* 5.81* .02* 5.61† 1.38† 9.84† .009† 
MCS 0.07 −0.04 0.18 .20 3.28 −1.11 7.67 .14 2.16 −0.72 5.04 .14 5.44* 0.77* 10.11* .02* 
FACT trial outcome index 0.005 −0.15 0.16 .95 3.19 −3.06 9.43 .32 5.53* 1.47* 9.60* .01* 8.72* 2.08* 15.36* .01* 
Physical functioning −0.20† −0.31† −0.09† .0006† 2.10 −2.29 6.50 .35 3.06* 0.18* 5.93* .04* 5.16* 0.48* 9.84* .03* 
Role-physical −0.06 −0.18 0.06 .29 4.31 −0.38 8.99 .07 4.17† 1.13† 7.22† .008† 8.48† 3.50† 13.46† .0009† 
Bodily pain 0.06 −0.05 0.18 .28 1.59 −2.91 6.09 .49 2.81 −0.11 5.72 .06 4.40 −0.38 9.17 .07 
General health 0.006 −0.09 0.11 .91 3.11 −0.86 7.07 .12 2.86* 0.29* 5.43* .03* 5.97† 1.76† 10.17† .006† 
Vitality −0.10 −0.21 0.01 .09 2.79 −1.68 7.25 .22 3.36* 0.47* 6.26* .02* 6.15* 1.40* 10.90* .01* 
Social functioning 0.02 −0.11 0.15 .78 2.08 −3.01 7.17 .42 4.08* 0.79* 7.38* .02* 6.17* 0.76* 11.58* .03* 
Role-emotional 0.005 −0.13 0.14 .95 4.35 −0.95 9.65 .11 3.35 −0.09 6.80 .06 7.70* 2.07* 13.34* .007* 
Mental health 0.07 −0.04 0.17 .20 2.92 −1.19 7.03 .16 1.65 −1.01 4.32 .22 4.57* 0.20* 8.94* .04* 
FACT total 0.07 −0.09 0.24 .37 2.74 −3.68 9.15 .40 5.94† 1.76† 10.12† .006† 8.68* 1.86* 15.50* .01* 
FACT-BMT total 0.06 −0.15 0.27 .59 4.37 −4.04 12.77 .31 7.77† 2.30† 13.24† .006† 12.14† 3.20† 21.07† .008† 
Age
Mild vs moderate
Moderate vs severe
Mild vs severe
Estimate95% lower95% upperPEstimate95% lower95% upperPEstimate95% lower95% upperPEstimate95% lower95% upperP
PCS −0.11* −0.21* −0.004* .04* 2.41 −1.57 6.39 .23 3.20* 0.60* 5.81* .02* 5.61† 1.38† 9.84† .009† 
MCS 0.07 −0.04 0.18 .20 3.28 −1.11 7.67 .14 2.16 −0.72 5.04 .14 5.44* 0.77* 10.11* .02* 
FACT trial outcome index 0.005 −0.15 0.16 .95 3.19 −3.06 9.43 .32 5.53* 1.47* 9.60* .01* 8.72* 2.08* 15.36* .01* 
Physical functioning −0.20† −0.31† −0.09† .0006† 2.10 −2.29 6.50 .35 3.06* 0.18* 5.93* .04* 5.16* 0.48* 9.84* .03* 
Role-physical −0.06 −0.18 0.06 .29 4.31 −0.38 8.99 .07 4.17† 1.13† 7.22† .008† 8.48† 3.50† 13.46† .0009† 
Bodily pain 0.06 −0.05 0.18 .28 1.59 −2.91 6.09 .49 2.81 −0.11 5.72 .06 4.40 −0.38 9.17 .07 
General health 0.006 −0.09 0.11 .91 3.11 −0.86 7.07 .12 2.86* 0.29* 5.43* .03* 5.97† 1.76† 10.17† .006† 
Vitality −0.10 −0.21 0.01 .09 2.79 −1.68 7.25 .22 3.36* 0.47* 6.26* .02* 6.15* 1.40* 10.90* .01* 
Social functioning 0.02 −0.11 0.15 .78 2.08 −3.01 7.17 .42 4.08* 0.79* 7.38* .02* 6.17* 0.76* 11.58* .03* 
Role-emotional 0.005 −0.13 0.14 .95 4.35 −0.95 9.65 .11 3.35 −0.09 6.80 .06 7.70* 2.07* 13.34* .007* 
Mental health 0.07 −0.04 0.17 .20 2.92 −1.19 7.03 .16 1.65 −1.01 4.32 .22 4.57* 0.20* 8.94* .04* 
FACT total 0.07 −0.09 0.24 .37 2.74 −3.68 9.15 .40 5.94† 1.76† 10.12† .006† 8.68* 1.86* 15.50* .01* 
FACT-BMT total 0.06 −0.15 0.27 .59 4.37 −4.04 12.77 .31 7.77† 2.30† 13.24† .006† 12.14† 3.20† 21.07† .008† 

Multivariable models examining QOL outcomes (SF-36 summary PCS and MCS, and subscales; FACT trial outcome index, FACT total, and FACT-BMT total) according to chronic GVHD severity.

MCS indicates mental component score; QOL, quality of life; and PCS, physical component score.

*

P < .05.

†

P < .01

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