Canonical pathways and the corresponding overexpressed genes correlated with chronic ITP
| Ingenuity canonical pathways . | Pathway categories . | Genes overexpressed in chronic ITP . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Intracellular and second messenger signaling . | Cellular immune response . | Cytokine signaling . | Humoral immune response . | Nuclear receptor signaling . | Organismal growth and development . | Apoptosis . | Cellular stress and injury . | ||
| ERK5 signaling | X | — | — | — | — | — | — | — | GNAQ, RPS6KA5, FOS, MAP3K2, CREB5, MAP3K3, FOXO3, SGK1 |
| Production of nitric oxide and ROS in macrophages | — | X | — | — | — | — | — | — | CREBBP, TLR2, SIRPA, PPP1R3D, RAP1A, CYBB, FOS, PIK3CD, MAP3K2, IFNG, NCF4, MAP3K3 |
| NF-κB signaling | — | X | X | X | — | — | — | — | CREBBP, TLR2, GSK3B, PIK3CD, TLR1, IL1R1, MAP4K4, MAP3K3, IL1RN, TNFSF13B, IL1R2 |
| IL-10 signaling | — | X | X | — | — | — | — | — | SOCS3, FOS, IL1R1, MAP4K4, CCR1, IL1RN, IL1R2 |
| PPAR signaling | — | — | — | — | X | — | — | — | CREBBP, FOS, IL1R1, NCOA1, MAP4K4, IL1RN, IL1R2 |
| BCR signaling | — | — | — | X | — | — | — | — | LYN, GSK3B, PIK3CD, MAP3K2, GAB2, CREB5, MAP3K3, BCL6, PPP3CA |
| IL-3 signaling | — | X | — | — | — | — | — | — | FOS, CSF2RB, PIK3CD, GAB2, PPP3CA, PAK1 |
| Actin cytoskeleton signaling | — | — | — | — | — | X | — | — | MSN, PIK3CD, SSH2, IQGAP1, LIMK2, MYH9, PXN, IQGAP2, GSN, PPP1R12B, PAK1 |
| ERK/MAPK signaling | X | — | — | — | — | — | — | — | RPS6KA5, PPP1R3D, RAP1A, DUSP1, FOS, PIK3CD, CREB5, PXN, H3F3A, PAK1 |
| p38 MAPK signaling | X | X | X | X | — | — | — | X | RPS6KA5, DUSP1, IL1R1, CREB5, IL1RN, H3F3A, IL1R2 |
| NRF2-mediated oxidative stress response | — | — | — | — | — | — | — | X | CREBBP, FOS, MAFG, GSK3B, SOD2, PIK3CD, SQSTM1, GSTO2, GSTM3 |
| Toll-like receptor signaling | — | X | — | X | — | — | X | TLR2, FOS, TLR1, MAP4K4 | |
| Communication between innate and adaptive immune cells | — | X | — | — | TLR2, TLR1, IFNG, IL1RN, TNFSF13B | ||||
| CD27 signaling in lymphocytes | — | X | — | — | — | — | X | — | FOS, MAP3K2, MAP3K3, BID |
| Altered T-cell and B-cell signaling in rheumatoid arthritis | — | X | — | — | — | — | — | — | TLR2, TLR1, IFNG, IL1RN, TNFSF13B |
| IL-6 signaling | — | X | X | — | — | — | — | — | FOS, IL1R1, MAP4K4, IL1RN, IL1R2 |
| CXCR4 signaling | — | X | X | — | — | — | — | — | GNAQ, GNG10, LYN, FOS, PIK3CD, PXN, PAK1 |
| Fc-γ receptor-mediated phagocytosis in macrophages and monocytes | — | X | — | — | — | — | — | — | LYN, GAB2, PXN, CBL, PAK1 |
| Ingenuity canonical pathways . | Pathway categories . | Genes overexpressed in chronic ITP . | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Intracellular and second messenger signaling . | Cellular immune response . | Cytokine signaling . | Humoral immune response . | Nuclear receptor signaling . | Organismal growth and development . | Apoptosis . | Cellular stress and injury . | ||
| ERK5 signaling | X | — | — | — | — | — | — | — | GNAQ, RPS6KA5, FOS, MAP3K2, CREB5, MAP3K3, FOXO3, SGK1 |
| Production of nitric oxide and ROS in macrophages | — | X | — | — | — | — | — | — | CREBBP, TLR2, SIRPA, PPP1R3D, RAP1A, CYBB, FOS, PIK3CD, MAP3K2, IFNG, NCF4, MAP3K3 |
| NF-κB signaling | — | X | X | X | — | — | — | — | CREBBP, TLR2, GSK3B, PIK3CD, TLR1, IL1R1, MAP4K4, MAP3K3, IL1RN, TNFSF13B, IL1R2 |
| IL-10 signaling | — | X | X | — | — | — | — | — | SOCS3, FOS, IL1R1, MAP4K4, CCR1, IL1RN, IL1R2 |
| PPAR signaling | — | — | — | — | X | — | — | — | CREBBP, FOS, IL1R1, NCOA1, MAP4K4, IL1RN, IL1R2 |
| BCR signaling | — | — | — | X | — | — | — | — | LYN, GSK3B, PIK3CD, MAP3K2, GAB2, CREB5, MAP3K3, BCL6, PPP3CA |
| IL-3 signaling | — | X | — | — | — | — | — | — | FOS, CSF2RB, PIK3CD, GAB2, PPP3CA, PAK1 |
| Actin cytoskeleton signaling | — | — | — | — | — | X | — | — | MSN, PIK3CD, SSH2, IQGAP1, LIMK2, MYH9, PXN, IQGAP2, GSN, PPP1R12B, PAK1 |
| ERK/MAPK signaling | X | — | — | — | — | — | — | — | RPS6KA5, PPP1R3D, RAP1A, DUSP1, FOS, PIK3CD, CREB5, PXN, H3F3A, PAK1 |
| p38 MAPK signaling | X | X | X | X | — | — | — | X | RPS6KA5, DUSP1, IL1R1, CREB5, IL1RN, H3F3A, IL1R2 |
| NRF2-mediated oxidative stress response | — | — | — | — | — | — | — | X | CREBBP, FOS, MAFG, GSK3B, SOD2, PIK3CD, SQSTM1, GSTO2, GSTM3 |
| Toll-like receptor signaling | — | X | — | X | — | — | X | TLR2, FOS, TLR1, MAP4K4 | |
| Communication between innate and adaptive immune cells | — | X | — | — | TLR2, TLR1, IFNG, IL1RN, TNFSF13B | ||||
| CD27 signaling in lymphocytes | — | X | — | — | — | — | X | — | FOS, MAP3K2, MAP3K3, BID |
| Altered T-cell and B-cell signaling in rheumatoid arthritis | — | X | — | — | — | — | — | — | TLR2, TLR1, IFNG, IL1RN, TNFSF13B |
| IL-6 signaling | — | X | X | — | — | — | — | — | FOS, IL1R1, MAP4K4, IL1RN, IL1R2 |
| CXCR4 signaling | — | X | X | — | — | — | — | — | GNAQ, GNG10, LYN, FOS, PIK3CD, PXN, PAK1 |
| Fc-γ receptor-mediated phagocytosis in macrophages and monocytes | — | X | — | — | — | — | — | — | LYN, GAB2, PXN, CBL, PAK1 |
ERK indicates extracellular signal-regulated kinase; X, presence; —, no presence; IL-10, interleukin-10; BCR, B-cell receptor; and MAPK, mitogen-activated protein kinase.