Summary of indications for allo-SCT in CML
| Phase . | Indications . |
|---|---|
| Blast | As soon as possible after re-establishing chronic phase with TKI or chemotherapy (consider use postengraftment therapy with second generation TKI) |
| Accelerated | Less advanced accelerated phase at diagnosis: treat as first chronic phase Near blast phase or evolution into accelerated phase on TKI: treat as blast phase |
| First chronic | Failure of second-generation TKI (donor search should be undertaken after failure of imatinib) imatinib failure and T315I BCR-ABL1 mutation |
| Phase . | Indications . |
|---|---|
| Blast | As soon as possible after re-establishing chronic phase with TKI or chemotherapy (consider use postengraftment therapy with second generation TKI) |
| Accelerated | Less advanced accelerated phase at diagnosis: treat as first chronic phase Near blast phase or evolution into accelerated phase on TKI: treat as blast phase |
| First chronic | Failure of second-generation TKI (donor search should be undertaken after failure of imatinib) imatinib failure and T315I BCR-ABL1 mutation |