Dosing chart for pig groups in cardiopulmonary bypass (CPB) model
| Group # . | Anticoagulant . | n . | Initial heparin mass equivalent (mg/kg) . | Initial heparin activity equivalent (U/kg) (range) . | Total heparin mass equivalent (mg/kg) . | Total heparin mass equivalent (U/kg) . | Total AT mass equivalent (mg/kg) . | Neutralizing protamine sulfate given (mg/kg) . |
|---|---|---|---|---|---|---|---|---|
| 1 | 300 U/kg UFH | 5 | 1.9 | 300 (300 - 456) | 2.6 | 421 | — | 0.52 |
| 2 | 1000 U/kg UFH | 5 | 6.3 | 1000 | 6.3 | 1000 | — | 1.94 |
| 3 | 1 mg/kg ATH | 3 | 0.4 | 225 | 0.6 | 393 | 2.0 | 1.18 |
| 4 | 2 mg/kg ATH | 6 | 0.6 | 385 | 0.8 | 512 | 2.7 | 1.06 |
| 5 | 3 mg/kg ATH | 5 | 1.1 | 677 | 1.1 | 707 | 3.6 | 1.59 |
| 6 | 6 mg/kg ATH | 4 | 1.9 | 1217 | 1.9 | 1217 | 6.0 | 1.29 |
| 7 | 3 mg/kg AT +300 U/kg UFH | 5 | 1.9 | 300 (300 - 375) | 2.2 | 345 | 3.0 | 1.06 |
| 8 | 6 mg/kg AT + 300 U/kg UFH | 4 | 1.9 | 300 | 2.7 | 420 | 6.0 | 1.05 |
| Group # . | Anticoagulant . | n . | Initial heparin mass equivalent (mg/kg) . | Initial heparin activity equivalent (U/kg) (range) . | Total heparin mass equivalent (mg/kg) . | Total heparin mass equivalent (U/kg) . | Total AT mass equivalent (mg/kg) . | Neutralizing protamine sulfate given (mg/kg) . |
|---|---|---|---|---|---|---|---|---|
| 1 | 300 U/kg UFH | 5 | 1.9 | 300 (300 - 456) | 2.6 | 421 | — | 0.52 |
| 2 | 1000 U/kg UFH | 5 | 6.3 | 1000 | 6.3 | 1000 | — | 1.94 |
| 3 | 1 mg/kg ATH | 3 | 0.4 | 225 | 0.6 | 393 | 2.0 | 1.18 |
| 4 | 2 mg/kg ATH | 6 | 0.6 | 385 | 0.8 | 512 | 2.7 | 1.06 |
| 5 | 3 mg/kg ATH | 5 | 1.1 | 677 | 1.1 | 707 | 3.6 | 1.59 |
| 6 | 6 mg/kg ATH | 4 | 1.9 | 1217 | 1.9 | 1217 | 6.0 | 1.29 |
| 7 | 3 mg/kg AT +300 U/kg UFH | 5 | 1.9 | 300 (300 - 375) | 2.2 | 345 | 3.0 | 1.06 |
| 8 | 6 mg/kg AT + 300 U/kg UFH | 4 | 1.9 | 300 | 2.7 | 420 | 6.0 | 1.05 |
UFH indicates unfractionated heparin; AT, antithrombin; and ATH, antithrombin-heparin covalent complex.