Table 1 SCID-repopulating cells . Cell... | American Society of Hematology

Table 1

SCID-repopulating cells

	Cell dose	Short-term SRCs			Long-term SRCs
	Cell dose	No. engrafted	No. assayed	%	No. engrafted	No. assayed	%
High	30 000	4	4	100	1	1	100
	10 000	11	11	100	9	11	81
Low	3000	12	12	100	4	7	57
	1000	6	8	75	2	8	25
	300	3	5	60	0	5	0
Total		36	40		16	32

	Cell dose	Short-term SRCs			Long-term SRCs
	Cell dose	No. engrafted	No. assayed	%	No. engrafted	No. assayed	%
High	30 000	4	4	100	1	1	100
	10 000	11	11	100	9	11	81
Low	3000	12	12	100	4	7	57
	1000	6	8	75	2	8	25
	300	3	5	60	0	5	0
Total		36	40		16	32

The mice that established short- and long-term SCID repopulation are tabularized both by the total number of mice that engrafted and as a percentage of the total assays performed. The data were stratified by progenitor cell dose. Mice receiving a “high” transplant dose received greater than the final estimated dose for long-term SRCs for ALDH^br CD34⁺ cells (4867 cells; see text); mice receiving a “low” transplant dose received less than that estimate. Short-term engraftment was defined 7 weeks after transplantation by the presence of human CD45⁺ hematopoietic cells within the peripheral blood. Long-term engraftment was defined ≥ 19 weeks after transplantation by the capacity to establish multiple-lineage hematopoietic development in multiple tissues.

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