Monitoring during surgery (step 3)
| Patient no./surgical procedure . | Treatment regimen . | ETP during surgery (nM.min) . | Post-operative ETP (nM.min) . | Intra-operative blood loss (mL) . | Hemoglobin (g/dL) before/after surgery . | Clinical outcome . |
|---|---|---|---|---|---|---|
| 1 | ||||||
| Transfemoral amputation of the left lower limb | D0: rFVIIa 200 μg/kg | 1567 (normalized) | D0: 1256 | 300 | D0: 14/11.5 | No excessive bleeding during surgery |
| D1: rFVIIa 90 μg/kg/2H | D1: 1312 | |||||
| D2: rFVIIa 90 μg/kg/3H | D2: 865 | D2: 6.5 | Hematoma into left adductor magnus (ultrasound) | |||
| 2 | ||||||
| Left total ankle arthroplasty | APCC 75 U/kg /8H | 1440 (normalized) | D0: 1236; D1: 1416; D2: 1139 | 500 | 15/12 | No excessive bleeding and satisfactory wound healing |
| 3 | ||||||
| Right elbow synovectomy | APCC 75 U/kg /8H | D0: 1600 ± 128 | 170 | 13/12 | No excessive bleeding and satisfactory wound healing | |
| Left total knee arthroplasty | APCC 75 U/kg /8H | 1417 ± 184 (mean ± SD; n = 4) | D1: 1238 ± 103 | 600 | 12/9.8 | |
| Right ankle replacement | APCC 75 U/kg /8H | (normalized) | D2: 1205 ± 111 | 250 | 12.8/11.5 | |
| Right total knee arthroplasty | APCC 75 U/kg /8H | 450 | 13/11 | |||
| 4 | ||||||
| Bilateral total knee arthroplasty | Immunoadsorption; FVIII concentrate; APCC 75 U/kg at D4 | 1027 (low ETP) | D0: 957; D2: 884; D4: 1009 | 600 × 2 | 12/8 | No excessive bleeding and satisfactory wound healing |
| 5 | ||||||
| Cataract surgery | rFVIIa 120 μg/kg | 956 (low ETP) | D0: 938; D1: 654 | 0 | 13/13.1 | No excessive bleeding and satisfactory wound healing |
| Partial colectomy | D0-D4: rFVIIa 120 μg/kg/2H | 832 | D0-D4: 752 ± 92 | NA | D0: 10.5/8.2 | Death by excessive bleeding |
| D5: APCC 100 U/kg/8H | (low ETP) | D5: 869 | D5: 6.3 | |||
| 6 | ||||||
| Left elbow synovectomy | rFVIIa 90 μg/kg/2H | 1903 (normalized) | D0: 1935; D1: 1789; D2: 1566 | < 100 | 12.5/12 | No excessive bleeding and satisfactory wound healing |
| Patient no./surgical procedure . | Treatment regimen . | ETP during surgery (nM.min) . | Post-operative ETP (nM.min) . | Intra-operative blood loss (mL) . | Hemoglobin (g/dL) before/after surgery . | Clinical outcome . |
|---|---|---|---|---|---|---|
| 1 | ||||||
| Transfemoral amputation of the left lower limb | D0: rFVIIa 200 μg/kg | 1567 (normalized) | D0: 1256 | 300 | D0: 14/11.5 | No excessive bleeding during surgery |
| D1: rFVIIa 90 μg/kg/2H | D1: 1312 | |||||
| D2: rFVIIa 90 μg/kg/3H | D2: 865 | D2: 6.5 | Hematoma into left adductor magnus (ultrasound) | |||
| 2 | ||||||
| Left total ankle arthroplasty | APCC 75 U/kg /8H | 1440 (normalized) | D0: 1236; D1: 1416; D2: 1139 | 500 | 15/12 | No excessive bleeding and satisfactory wound healing |
| 3 | ||||||
| Right elbow synovectomy | APCC 75 U/kg /8H | D0: 1600 ± 128 | 170 | 13/12 | No excessive bleeding and satisfactory wound healing | |
| Left total knee arthroplasty | APCC 75 U/kg /8H | 1417 ± 184 (mean ± SD; n = 4) | D1: 1238 ± 103 | 600 | 12/9.8 | |
| Right ankle replacement | APCC 75 U/kg /8H | (normalized) | D2: 1205 ± 111 | 250 | 12.8/11.5 | |
| Right total knee arthroplasty | APCC 75 U/kg /8H | 450 | 13/11 | |||
| 4 | ||||||
| Bilateral total knee arthroplasty | Immunoadsorption; FVIII concentrate; APCC 75 U/kg at D4 | 1027 (low ETP) | D0: 957; D2: 884; D4: 1009 | 600 × 2 | 12/8 | No excessive bleeding and satisfactory wound healing |
| 5 | ||||||
| Cataract surgery | rFVIIa 120 μg/kg | 956 (low ETP) | D0: 938; D1: 654 | 0 | 13/13.1 | No excessive bleeding and satisfactory wound healing |
| Partial colectomy | D0-D4: rFVIIa 120 μg/kg/2H | 832 | D0-D4: 752 ± 92 | NA | D0: 10.5/8.2 | Death by excessive bleeding |
| D5: APCC 100 U/kg/8H | (low ETP) | D5: 869 | D5: 6.3 | |||
| 6 | ||||||
| Left elbow synovectomy | rFVIIa 90 μg/kg/2H | 1903 (normalized) | D0: 1935; D1: 1789; D2: 1566 | < 100 | 12.5/12 | No excessive bleeding and satisfactory wound healing |