Multivariate Cox regression analysis of the prognostic significance of the risk group determined by the combined gene expression classifier for RFS and flow cytometric measures of MRD in the presence of genetic factors in ALL associated with a poor outcome
| Covariates . | Hazard ratio* . | P . | |
|---|---|---|---|
| Estimate . | 95% confidence interval . | ||
| Risk group determined by gene expression classifier for RFS and flow MRD | |||
| Intermediate versus low risk | 3.366 | 1.569-7.222 | .002 |
| High versus low risk | 6.214 | 2.547-15.160 | .000 |
| IKAROS/IKZF1 deletions | |||
| Positive versus negative | 1.684 | .923-3.072 | .089 |
| JAK mutations | |||
| Positive versus negative | .987 | .469-2.076 | .973 |
| Kinase gene expression signature | |||
| Positive versus negative | .988 | .506-1.929 | .972 |
| Covariates . | Hazard ratio* . | P . | |
|---|---|---|---|
| Estimate . | 95% confidence interval . | ||
| Risk group determined by gene expression classifier for RFS and flow MRD | |||
| Intermediate versus low risk | 3.366 | 1.569-7.222 | .002 |
| High versus low risk | 6.214 | 2.547-15.160 | .000 |
| IKAROS/IKZF1 deletions | |||
| Positive versus negative | 1.684 | .923-3.072 | .089 |
| JAK mutations | |||
| Positive versus negative | .987 | .469-2.076 | .973 |
| Kinase gene expression signature | |||
| Positive versus negative | .988 | .506-1.929 | .972 |
The gene expression classifier for RFS used in this analysis is the initial classifier developed with 42 probe sets (38 unique genes) provided in supplemental Table 4.
Hazard ratios and corresponding P value are based on Cox regression.