Multivariate Cox regression analysis of the prognostic significance of the risk group determined by the gene expression classifier for RFS in the presence of genetic factors in ALL associated with a poor outcome
| Covariates . | Hazard ratio* . | P . | |
|---|---|---|---|
| Estimate . | 95% confidence interval . | ||
| Gene expression classifier for RFS risk group | |||
| High risk versus low risk | 2.380 | 2.3.6-4.338 | .005 |
| IKAROS/IKZF1 deletions | |||
| Positive versus negative | 2.237 | 1.316-3.803 | .003 |
| JAK mutations | |||
| Positive versus negative | 1.020 | .500-2.081 | .957 |
| Kinase gene expression signature | |||
| Positive versus negative | 1.094 | .590-2.030 | .774 |
| Covariates . | Hazard ratio* . | P . | |
|---|---|---|---|
| Estimate . | 95% confidence interval . | ||
| Gene expression classifier for RFS risk group | |||
| High risk versus low risk | 2.380 | 2.3.6-4.338 | .005 |
| IKAROS/IKZF1 deletions | |||
| Positive versus negative | 2.237 | 1.316-3.803 | .003 |
| JAK mutations | |||
| Positive versus negative | 1.020 | .500-2.081 | .957 |
| Kinase gene expression signature | |||
| Positive versus negative | 1.094 | .590-2.030 | .774 |
The gene expression classifier for RFS used in this analysis is the initial classifier developed with 42 probe sets (38 unique genes) provided in supplemental Table 4.
Hazard ratios and corresponding P value are based on Cox regression.