Clinical data of the MCL patients investigated with 500K SNP arrays
| . | All cases, no. (%) . | Cyclin D1+, no. (%) . | Cyclin D1−, no. (%) . |
|---|---|---|---|
| No. of patients | 77 | 72 (94) | 5 (6) |
| Median age at diagnosis, y (range) | 61 (38-93) | 63 (38-93) | 60 (54-77) |
| Sex | |||
| Male | 58 (75) | 54 (75) | 4 (80) |
| Female | 19 (25) | 18 (25) | 1 (20) |
| Morphology | |||
| Classic | 67 (87) | 62 (86) | 5 (100) |
| Blastoid | 10 (13) | 10 (14) | 0 |
| B symptoms | 26 (34) | 25 (35) | 1 (20) |
| Ann Arbor stage | |||
| I/II | 9 (12) | 9 (13) | 0 |
| III/IV | 68 (88) | 63 (87) | 5 (100) |
| BM involvement | 46 (60) | 41 (57) | 5 (100) |
| LDH level more than normal | 26 (34) | 25 (35) | 1 (20) |
| Therapy* | |||
| Combined chemotherapy | 63 (82) | 58 (81) | 5 (100) |
| Combined chemotherapy plus rituximab | 8 (10) | 8 (11) | 0 |
| No chemotherapy | 4 (5) | 4 (6) | 0 |
| Response to therapy (CR + PR) | 58 of 74 (78) | 53 of 69 (77) | 5 of 5 (100) |
| Median follow-up, months | 33 | 32 | 38 |
| Median survival (range), months† | 37 (24-50) | 35 (21-48) | NR |
| . | All cases, no. (%) . | Cyclin D1+, no. (%) . | Cyclin D1−, no. (%) . |
|---|---|---|---|
| No. of patients | 77 | 72 (94) | 5 (6) |
| Median age at diagnosis, y (range) | 61 (38-93) | 63 (38-93) | 60 (54-77) |
| Sex | |||
| Male | 58 (75) | 54 (75) | 4 (80) |
| Female | 19 (25) | 18 (25) | 1 (20) |
| Morphology | |||
| Classic | 67 (87) | 62 (86) | 5 (100) |
| Blastoid | 10 (13) | 10 (14) | 0 |
| B symptoms | 26 (34) | 25 (35) | 1 (20) |
| Ann Arbor stage | |||
| I/II | 9 (12) | 9 (13) | 0 |
| III/IV | 68 (88) | 63 (87) | 5 (100) |
| BM involvement | 46 (60) | 41 (57) | 5 (100) |
| LDH level more than normal | 26 (34) | 25 (35) | 1 (20) |
| Therapy* | |||
| Combined chemotherapy | 63 (82) | 58 (81) | 5 (100) |
| Combined chemotherapy plus rituximab | 8 (10) | 8 (11) | 0 |
| No chemotherapy | 4 (5) | 4 (6) | 0 |
| Response to therapy (CR + PR) | 58 of 74 (78) | 53 of 69 (77) | 5 of 5 (100) |
| Median follow-up, months | 33 | 32 | 38 |
| Median survival (range), months† | 37 (24-50) | 35 (21-48) | NR |