Interaction of JAK2 V617F status and leukocyte count (multivariable model)
| Interaction . | No.* (%) . | Events (%) . | Rate % pt-yr (95% CI) . | Hazard ratio (95% CI) . |
|---|---|---|---|---|
| (1) JAK2 wild type + low WBC count | 124 (30) | 4 (3) | 1.07 (0.66-1.73) | 1 (reference) |
| (2) JAK2 wild type + high WBC count† | 31 (8) | 2 (6) | 2.28 (1.42-3.68) | 1.95 (0.84-4.52) |
| (3) JAK2 V617F + low WBC count | 194 (48) | 17 (9) | 2.61 (1.36-5.01) | 2.06 (1.03-4.12) |
| (4) JAK2 V617F + high WBC count† | 58 (14) | 7 (12) | 3.92 (1.87-8.22) | 3.13 (1.26-7.81) |
| Interaction . | No.* (%) . | Events (%) . | Rate % pt-yr (95% CI) . | Hazard ratio (95% CI) . |
|---|---|---|---|---|
| (1) JAK2 wild type + low WBC count | 124 (30) | 4 (3) | 1.07 (0.66-1.73) | 1 (reference) |
| (2) JAK2 wild type + high WBC count† | 31 (8) | 2 (6) | 2.28 (1.42-3.68) | 1.95 (0.84-4.52) |
| (3) JAK2 V617F + low WBC count | 194 (48) | 17 (9) | 2.61 (1.36-5.01) | 2.06 (1.03-4.12) |
| (4) JAK2 V617F + high WBC count† | 58 (14) | 7 (12) | 3.92 (1.87-8.22) | 3.13 (1.26-7.81) |
Values in bold are statistically significant (P < .05).
Multivariable model was adjusted for sex, age, previous thrombosis, hemoglobin, and platelet levels.
CI indicates confidence interval; and WBC, white blood cell.
Performed on 407 patients with JAK2 mutational status and WBC count available at diagnosis.
WBC count was 15 × 109/L or higher.