Comparison of MC with novel methods of karyotyping using array-based whole genome scanning
| Feature . | Technique . | |||||
|---|---|---|---|---|---|---|
| MC . | SNP-A . | SNP/Copy no. oligo arrays . | Oligo/BAC CGH-A . | FISH . | SKY . | |
| Resolution | + | ++++ | ++++ | ++++/++ | ++ | +++ |
| Sensitivity | + | + | + | + | +++ | + |
| Copy neutral LOH | − | + | + | − | − | − |
| Need for cell division | + | − | − | − | − | + |
| Detection of balanced lesions | + | − | − | − | + | − |
| Distinction of multiple clones | + | − | − | − | + | − |
| Screening for unknown defects | + | + | + | + | − | + |
| Feature . | Technique . | |||||
|---|---|---|---|---|---|---|
| MC . | SNP-A . | SNP/Copy no. oligo arrays . | Oligo/BAC CGH-A . | FISH . | SKY . | |
| Resolution | + | ++++ | ++++ | ++++/++ | ++ | +++ |
| Sensitivity | + | + | + | + | +++ | + |
| Copy neutral LOH | − | + | + | − | − | − |
| Need for cell division | + | − | − | − | − | + |
| Detection of balanced lesions | + | − | − | − | + | − |
| Distinction of multiple clones | + | − | − | − | + | − |
| Screening for unknown defects | + | + | + | + | − | + |
Plus and minus signs indicate increases and decreases in the quality of individual methods.
LOH indicates loss of heterozygosity.