Algorithm of diagnosing early MF developed by the ISCL8
| . | Criteria . | Scoring system . | |||
|---|---|---|---|---|---|
| Basic . | Additional . | Other . | 2 points . | 1 point . | |
| Clinical | Persistent and/or progressive patches/thin plaques | (1) Non–sun-exposed location | 2 points for basic criteria and 2 additional criteria | 1 point for basic criteria and 1 additional criteria | |
| (2) Size/shape variation | |||||
| (3) Poikiloderma | |||||
| Histopathologic | Superficial lymphoid infiltrate | (1) Epidermotropism without spongiosis | 2 points for basic criteria and 2 additional criteria | 1 point for basic criteria and 1 additional criteria | |
| (2) Lymphoid atypia* | |||||
| Molecular biologic | Clonal T-cell receptor gene rearrangement | 1 point for clonality | |||
| Immunopathologic | < 50% CD2+, CD3+, and/or CD5+ cells | 1 point for 1 or more criteria | |||
| < 10% CD7+ cells | |||||
| Epidermal/dermal discordance of CD2, CD3, CD5, or CD7† | |||||
| . | Criteria . | Scoring system . | |||
|---|---|---|---|---|---|
| Basic . | Additional . | Other . | 2 points . | 1 point . | |
| Clinical | Persistent and/or progressive patches/thin plaques | (1) Non–sun-exposed location | 2 points for basic criteria and 2 additional criteria | 1 point for basic criteria and 1 additional criteria | |
| (2) Size/shape variation | |||||
| (3) Poikiloderma | |||||
| Histopathologic | Superficial lymphoid infiltrate | (1) Epidermotropism without spongiosis | 2 points for basic criteria and 2 additional criteria | 1 point for basic criteria and 1 additional criteria | |
| (2) Lymphoid atypia* | |||||
| Molecular biologic | Clonal T-cell receptor gene rearrangement | 1 point for clonality | |||
| Immunopathologic | < 50% CD2+, CD3+, and/or CD5+ cells | 1 point for 1 or more criteria | |||
| < 10% CD7+ cells | |||||
| Epidermal/dermal discordance of CD2, CD3, CD5, or CD7† | |||||
A total of 4 points is required for the diagnosis of MF based on any combination of points from the clinical, histopathologic, molecular biologic, and immunopathologic criteria.
Lymphoid atypical is defined as cells with enlarged hyperchromatic nuclei and irregular or cerebriform nuclear contours.
T-cell antigen deficiency confined to the epidermis.