Oral administration of VAG539 results in induction of active tolerance
| Treatment, days 0-30 . | No rejection (%) . | No rejection after challenge (%) . |
|---|---|---|
| VAG539, 30 mg/kg per d | 11/16 (69) | 7/9 (78) |
| Saline | 2/22 (9) | 0/2 (0) |
| Treatment, days 0-30 . | No rejection (%) . | No rejection after challenge (%) . |
|---|---|---|
| VAG539, 30 mg/kg per d | 11/16 (69) | 7/9 (78) |
| Saline | 2/22 (9) | 0/2 (0) |
Diabetic Balb/c mice received a transplant of C57B1/6 pancreatic islets and were treated orally with VAG539 or with saline. Mice that remained normoglycemic for more than 100 days were injected intraperitoneally with 3 × 107 C57B1/6 splenocytes.