Table 3 Frequency and absolute numbers... | American Society of Hematology

Table 3

Frequency and absolute numbers of subsets of LSK cells in Ptpn11^D61Y mice

	Bone marrow		Spleen
	Control	Ptpn11^D61Y	Control	Ptpn11^D61Y
LT-HSC, %*	0.02 ± 0.005	0.004 ± 0.001‡	0.005 ± 0.002	0.004 ± 0.001
LT-HSC, ×10³*	5.2 ± 1.5	0.7 ± 0.2‡	2.38 ± 1.63	6.9 ± 1.8
ST-HSC, %†	0.03 ± 0.01	0.05 ± 0.02	0.003 ± 0.001	0.03 ± 0.006‡
ST-HSC, ×10³†	9.6 ± 3.5	8.7 ± 4.3	1.10 ± 0.7	51.0 ± 11.9‡
MPP, %†	0.02 ± 0.004	0.04 ± 0.01	0.0008 ± 0.0004	0.01 ± 0.002‡
MPP, ×10³†	5.2 ± 2.5	7.6 ± 2.5	0.316 ± 0.226	14.8 ± 2.2‡

	Bone marrow		Spleen
	Control	Ptpn11^D61Y	Control	Ptpn11^D61Y
LT-HSC, %*	0.02 ± 0.005	0.004 ± 0.001‡	0.005 ± 0.002	0.004 ± 0.001
LT-HSC, ×10³*	5.2 ± 1.5	0.7 ± 0.2‡	2.38 ± 1.63	6.9 ± 1.8
ST-HSC, %†	0.03 ± 0.01	0.05 ± 0.02	0.003 ± 0.001	0.03 ± 0.006‡
ST-HSC, ×10³†	9.6 ± 3.5	8.7 ± 4.3	1.10 ± 0.7	51.0 ± 11.9‡
MPP, %†	0.02 ± 0.004	0.04 ± 0.01	0.0008 ± 0.0004	0.01 ± 0.002‡
MPP, ×10³†	5.2 ± 2.5	7.6 ± 2.5	0.316 ± 0.226	14.8 ± 2.2‡

Frequency (as percentage of total BM or spleen cells) and absolute numbers of cells in various hematopoietic compartments (± SEM). LT-HSCs (CD34⁻Flk2⁻-Lin⁻Sca1⁺cKit⁺); ST-HSCs (CD34⁺Flk2⁻-Lin⁻Sca1⁺cKit⁺); and MPPs (CD34⁺Flk2⁺-Lin⁻Sca1⁺cKit⁺).

n = 6.

†

n = 5

‡

P<.05 by unpaired 2-tailed Student t test.

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