Logistic regression models examining the odds of access thrombosis associated with the TGF-β1 production haplotypes, PAI-1 genotype, and their interaction in hemodialysis patients
Model, by TGF-β1 production haplotype/PAI-1 genotype . | TGF-β1 production haplotype . | . | PAI-1 genotype . | . | Interaction between TGF-β1 production haplotype and PAI-1 genotype . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| Unadjusted model | |||||||||
| High/5G/5G | Reference | Reference | Reference | Reference | — | — | |||
| Intermediate/4G/5G | 1.30 (0.74-2.29) | .355 | 1.63 (0.87-3.03) | .127 | — | — | |||
| Low/4G/4G | 5.11 (1.93-13.55) | .001 | 1.37 (0.66-2.81) | .399 | 8.23 (1.47-45.97) | .016 | |||
| Model 1 adjusted for thrombophilia | |||||||||
| Intermediate/4G/5G | 1.22 (0.69-2.16) | .501 | 1.77 (0.94-3.34) | .078 | — | — | |||
| Low/4G/4G | 6.16 (2.26-16.79) | < .001 | 1.44 (0.69-2.99) | .334 | 9.63 (1.67-55.61) | .011 | |||
| Model 1 adjusted for thrombophilia and access type | |||||||||
| Intermediate/4G/5G | 1.05 (0.57-1.91) | .881 | 1.52 (0.79-2.91) | .211 | — | — | |||
| Low/4G/4G | 5.00 (1.74-14.42) | .003 | 1.21 (0.57-2.59) | .620 | 9.75 (1.57-60.59) | .015 | |||
| Model 1 adjusted for several factors* | |||||||||
| Intermediate/4G/5G | 1.39 (0.70-2.75) | .347 | 1.59 (0.77-3.30) | .214 | — | — | |||
| Low/4G/4G | 7.31 (2.15-24.88) | .001 | 1.56 (0.67-3.65) | .303 | 19.32 (2.82-132.40) | .003 | |||
Model, by TGF-β1 production haplotype/PAI-1 genotype . | TGF-β1 production haplotype . | . | PAI-1 genotype . | . | Interaction between TGF-β1 production haplotype and PAI-1 genotype . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| . | OR (95% CI) . | P . | OR (95% CI) . | P . | OR (95% CI) . | P . | |||
| Unadjusted model | |||||||||
| High/5G/5G | Reference | Reference | Reference | Reference | — | — | |||
| Intermediate/4G/5G | 1.30 (0.74-2.29) | .355 | 1.63 (0.87-3.03) | .127 | — | — | |||
| Low/4G/4G | 5.11 (1.93-13.55) | .001 | 1.37 (0.66-2.81) | .399 | 8.23 (1.47-45.97) | .016 | |||
| Model 1 adjusted for thrombophilia | |||||||||
| Intermediate/4G/5G | 1.22 (0.69-2.16) | .501 | 1.77 (0.94-3.34) | .078 | — | — | |||
| Low/4G/4G | 6.16 (2.26-16.79) | < .001 | 1.44 (0.69-2.99) | .334 | 9.63 (1.67-55.61) | .011 | |||
| Model 1 adjusted for thrombophilia and access type | |||||||||
| Intermediate/4G/5G | 1.05 (0.57-1.91) | .881 | 1.52 (0.79-2.91) | .211 | — | — | |||
| Low/4G/4G | 5.00 (1.74-14.42) | .003 | 1.21 (0.57-2.59) | .620 | 9.75 (1.57-60.59) | .015 | |||
| Model 1 adjusted for several factors* | |||||||||
| Intermediate/4G/5G | 1.39 (0.70-2.75) | .347 | 1.59 (0.77-3.30) | .214 | — | — | |||
| Low/4G/4G | 7.31 (2.15-24.88) | .001 | 1.56 (0.67-3.65) | .303 | 19.32 (2.82-132.40) | .003 | |||
TGF-β1 indicates transforming growth factor-β1; PAI-1, plasminogen activator inhibitor type 1; OR, odds ratio; CI, confidence interval; —, not significant.
Factors include thrombophilia, access type, time of follow-up of the access, location of the access, average albumin, average urea reduction ratio, and average arterial pressure before event.