Relative Risk and Annual Incidence for all Thromboses (venous and arterial), Venous Thrombosis (deep and superficial veins), and Venous Thromboembolism Only (deep vein thrombosis with or without pulmonary embolism) for Each Thrombophilic Defect
| . | Yes . | No . | Conditional Risk Ratio (95% CI) . | Incidence of Thrombosis (per 100 patient-yr) . |
|---|---|---|---|---|
| All thromboses | ||||
| No defect | 15 | 312 | 1 (Ref.) | 0.15 |
| Antithrombin deficiency | 30 | 55 | 8.1 (3.4-19.6) | 1.0 |
| Protein C deficiency | 19 | 45 | 7.3 (2.9-18.4) | 0.85 |
| Protein S deficiency | 15 | 26 | 8.5 (3.5-20.8) | 1.0 |
| Factor V Leiden | 35 | 165 | 2.2 (1.1-4.7) | 0.29 |
| Venous thrombosis | ||||
| No defect | 9 | 312 | 1 (Ref.) | 0.09 |
| Antithrombin deficiency | 30 | 55 | 8.1 (3.4-19.6) | 1.0 |
| Protein C deficiency | 16 | 45 | 7.4 (2.7-20.5) | 0.72 |
| Protein S deficiency | 12 | 26 | 10.4 (3.8-28.7) | 0.78 |
| Factor V Leiden | 30 | 165 | 4.6 (1.5-13.7) | 0.25 |
| Venous thromboembolism | ||||
| No defect | 3 | 312 | 1 (Ref.) | 0.03 |
| Antithrombin deficiency | 27 | 55 | 42.8 (10.2-180.3) | 0.93 |
| Protein C deficiency | 14 | 45 | 31.3 (7.0-138.8) | 0.63 |
| Protein S deficiency | 12 | 26 | 35.7 (7.9-160.1) | 0.78 |
| Factor V Leiden | 17 | 165 | 10.1 (2.3-43.7) | 0.14 |
| . | Yes . | No . | Conditional Risk Ratio (95% CI) . | Incidence of Thrombosis (per 100 patient-yr) . |
|---|---|---|---|---|
| All thromboses | ||||
| No defect | 15 | 312 | 1 (Ref.) | 0.15 |
| Antithrombin deficiency | 30 | 55 | 8.1 (3.4-19.6) | 1.0 |
| Protein C deficiency | 19 | 45 | 7.3 (2.9-18.4) | 0.85 |
| Protein S deficiency | 15 | 26 | 8.5 (3.5-20.8) | 1.0 |
| Factor V Leiden | 35 | 165 | 2.2 (1.1-4.7) | 0.29 |
| Venous thrombosis | ||||
| No defect | 9 | 312 | 1 (Ref.) | 0.09 |
| Antithrombin deficiency | 30 | 55 | 8.1 (3.4-19.6) | 1.0 |
| Protein C deficiency | 16 | 45 | 7.4 (2.7-20.5) | 0.72 |
| Protein S deficiency | 12 | 26 | 10.4 (3.8-28.7) | 0.78 |
| Factor V Leiden | 30 | 165 | 4.6 (1.5-13.7) | 0.25 |
| Venous thromboembolism | ||||
| No defect | 3 | 312 | 1 (Ref.) | 0.03 |
| Antithrombin deficiency | 27 | 55 | 42.8 (10.2-180.3) | 0.93 |
| Protein C deficiency | 14 | 45 | 31.3 (7.0-138.8) | 0.63 |
| Protein S deficiency | 12 | 26 | 35.7 (7.9-160.1) | 0.78 |
| Factor V Leiden | 17 | 165 | 10.1 (2.3-43.7) | 0.14 |
Conditional risk ratios are adjusted by sex and family status.