Table 1.

Mice with the chronic myelogenous leukemia–like myeloproliferative disorder treated with STI571 demonstrate a marked reduction in white blood count and spleen weight

STI571-treated*Placebo
WBC, average, ×103/μL   
 Responding 23  (± 12) 409  (± 12)  
 All 153  (± 84)  
Spleen weight, mg   
 Responding 290  (± 40) 864  (± 92)  
 All 320  (± 33)  
STI571-treated*Placebo
WBC, average, ×103/μL   
 Responding 23  (± 12) 409  (± 12)  
 All 153  (± 84)  
Spleen weight, mg   
 Responding 290  (± 40) 864  (± 92)  
 All 320  (± 33)  

Standard errors are depicted in parentheses.

*

The data depicted are from the mice in Figure 2 and are representative of at least 3 independent bone marrow transplantation experiments.

Mice experiencing a hematologic response to STI571, recorded at time of analysis.

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