Complete, partial, or no response to fludarabine and CD38, soluble CD23, β2-microglobulin, soluble APO1/Fas, and soluble Bcl-2 levels
| Variable . | CR (n = 17) . | PR (n = 19) . | NR (n = 12) . |
|---|---|---|---|
| CD38+ (%)3-150 | |||
| More than 30 (n = 28) | 18% (6-37)3-154 | 46% (27-66) | 36% (19-56) |
| Less than 30 (n = 20) | 60% (36-81) | 30% (12-54) | 10% (1.2-32) |
| sCD23 (U/mL)3-151 | |||
| More than 60 (n = 20) | 15% (3-38) | 35% (15-59) | 50% (27-73) |
| Less than 60 (n = 28) | 50% (31-69) | 43% (24-63) | 7% (0.8-23) |
| β2-micro (μg/mL)3-152 | |||
| More than 2.2 (n = 36) | 25% (12-42) | 47% (30-64) | 28% (14-45) |
| Less than 2.2 (n = 10) | 70% (35-93) | 20% (2.5-56) | 10% (0.2-44) |
| sAPO1/Fas (ng/mL)3-153 | |||
| More than 7 (n = 20) | 35% (15-59) | 30% (12-54) | 35% (15-59) |
| Less than 7 (n = 24) | 38% (19-59) | 54% (33-74) | 8% (1-27) |
| sBcl-2 (U/mL)3-155 | |||
| More than 240 (n = 17) | 23.5% (7-50) | 23.5% (7-50) | 53% (28-77) |
| Less than 240 (n = 25) | 48% (28-69) | 40% (21-61) | 12% (2.5-31) |
| Variable . | CR (n = 17) . | PR (n = 19) . | NR (n = 12) . |
|---|---|---|---|
| CD38+ (%)3-150 | |||
| More than 30 (n = 28) | 18% (6-37)3-154 | 46% (27-66) | 36% (19-56) |
| Less than 30 (n = 20) | 60% (36-81) | 30% (12-54) | 10% (1.2-32) |
| sCD23 (U/mL)3-151 | |||
| More than 60 (n = 20) | 15% (3-38) | 35% (15-59) | 50% (27-73) |
| Less than 60 (n = 28) | 50% (31-69) | 43% (24-63) | 7% (0.8-23) |
| β2-micro (μg/mL)3-152 | |||
| More than 2.2 (n = 36) | 25% (12-42) | 47% (30-64) | 28% (14-45) |
| Less than 2.2 (n = 10) | 70% (35-93) | 20% (2.5-56) | 10% (0.2-44) |
| sAPO1/Fas (ng/mL)3-153 | |||
| More than 7 (n = 20) | 35% (15-59) | 30% (12-54) | 35% (15-59) |
| Less than 7 (n = 24) | 38% (19-59) | 54% (33-74) | 8% (1-27) |
| sBcl-2 (U/mL)3-155 | |||
| More than 240 (n = 17) | 23.5% (7-50) | 23.5% (7-50) | 53% (28-77) |
| Less than 240 (n = 25) | 48% (28-69) | 40% (21-61) | 12% (2.5-31) |
CR indicates complete remission; PR, partial remission; NR, no response or progression; n, number of observations.
P = .003. P values are determined by the proportional odds ordered logistic regression univariate model.
P = .001.
P = .018.
P = .238.
P = .012.
CI 95% throughout.