Intracellular Rh123 Retention and 3[H]DNR Retention/Accumulation Ratio in K562/ADM Cells and AML Blast Cells From Two Patients After Oligonucleotide Treatment
| . | K562/ADM . | AML Blast Cells . | |
|---|---|---|---|
| Case 8 . | Case 9 . | ||
| Rh123 retention (%) | |||
| Untreated | 13.3 | 16.5 | 40.4 |
| Random | 13.4 | 16.1 | 40.5 |
| MDR1-S | 11.7 | 15.9 | 42.1 |
| MDR1-AS | 37.4 | 23.4 | 49.1 |
| 3[H]DNR retention/accumulation ratio (%) | |||
| Untreated | 20.8 | 14.2 | 18.0 |
| Random | 19.6 | 19.3 | 16.5 |
| MDR1-S | 15.0 | 15.8 | 14.9 |
| MDR1-AS | 25.0 | 25.1 | 22.0 |
| . | K562/ADM . | AML Blast Cells . | |
|---|---|---|---|
| Case 8 . | Case 9 . | ||
| Rh123 retention (%) | |||
| Untreated | 13.3 | 16.5 | 40.4 |
| Random | 13.4 | 16.1 | 40.5 |
| MDR1-S | 11.7 | 15.9 | 42.1 |
| MDR1-AS | 37.4 | 23.4 | 49.1 |
| 3[H]DNR retention/accumulation ratio (%) | |||
| Untreated | 20.8 | 14.2 | 18.0 |
| Random | 19.6 | 19.3 | 16.5 |
| MDR1-S | 15.0 | 15.8 | 14.9 |
| MDR1-AS | 25.0 | 25.1 | 22.0 |
Data represent mean of two experiments.