Table 1.

Treatment Groups

Groups*Time (h)-151
−48−36 −24 −12 0 12 24 36 48 60
Controls: PBS 0.1 mL only-152 +  +  +  +   +  +  +  +  
G-CSF/pre: 50 μg/kg sc  +  +  +  
MoAb III/5-1: 10 mg/kg IV      
G-CSF/pre (×4) + MoAb III/5-1 (×1)  +  +  +  +  
G-CSF/post: 50 μg/kg sc        +  +  
Groups*Time (h)-151
−48−36 −24 −12 0 12 24 36 48 60
Controls: PBS 0.1 mL only-152 +  +  +  +   +  +  +  +  
G-CSF/pre: 50 μg/kg sc  +  +  +  
MoAb III/5-1: 10 mg/kg IV      
G-CSF/pre (×4) + MoAb III/5-1 (×1)  +  +  +  +  
G-CSF/post: 50 μg/kg sc        +  +  

*pre denotes treatment before induction of pneumonia; post denotes treatment after induction of pneumonia. MoAb III/5-1 was administered 1 hour before induction of pneumonia.

F0-151

Pneumonia was induced at 0 hours by intranasal instillation of 1 × 103 CFU of K pneumoniae B5055 as described in Materials and Methods.

F0-152

PBS was administered either IV (at −1 hour) or sc (all other time points).

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