Treatment Groups
Groups* . | Time (h)-151 . | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
−48 . | −36 . | −24 . | −12 . | 0 . | 12 . | 24 . | 36 . | 48 . | 60 . | |
Controls: PBS 0.1 mL only-152 | + | + | + | + | + | + | + | + | + | |
G-CSF/pre: 50 μg/kg sc | + | + | + | + | ||||||
MoAb III/5-1: 10 mg/kg IV | + | |||||||||
G-CSF/pre (×4) + MoAb III/5-1 (×1) | + | + | + | + | + | |||||
G-CSF/post: 50 μg/kg sc | + | + | + | + |
Groups* . | Time (h)-151 . | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
−48 . | −36 . | −24 . | −12 . | 0 . | 12 . | 24 . | 36 . | 48 . | 60 . | |
Controls: PBS 0.1 mL only-152 | + | + | + | + | + | + | + | + | + | |
G-CSF/pre: 50 μg/kg sc | + | + | + | + | ||||||
MoAb III/5-1: 10 mg/kg IV | + | |||||||||
G-CSF/pre (×4) + MoAb III/5-1 (×1) | + | + | + | + | + | |||||
G-CSF/post: 50 μg/kg sc | + | + | + | + |
*pre denotes treatment before induction of pneumonia; post denotes treatment after induction of pneumonia. MoAb III/5-1 was administered 1 hour before induction of pneumonia.
Pneumonia was induced at 0 hours by intranasal instillation of 1 × 103 CFU of K pneumoniae B5055 as described in Materials and Methods.
PBS was administered either IV (at −1 hour) or sc (all other time points).