Distribution of Mutations in VH Genes of HCV-Associated Lymphomas
| Patient . | VH Family . | Tumor Seq/ Clones Seq (Source) . | VH Gene . | % Homology . | R:S Mutations . | P* . | D Gene . | JH Gene . | |
|---|---|---|---|---|---|---|---|---|---|
| SS | VHI | 4/4 (PB) | 51p1 | 99.0 | CDR | 2:0 | .27 | DN4 | JH4b |
| FWR | 2:1 | .1 | |||||||
| SEG | VHI | 4/5 (BM) 2/3 (PB) | 51p1 | 96.3 | CDR FWR | 3:3 3:3 | .25 .004 | DK1 | JH4b |
| LC2 | VHI | 6/8 (PB) | 51p1 | 95.6 | CDR | 4:3 | .14 | DXP1 | JH4b |
| FWR | 8:7 | .0008 | |||||||
| LC3 | VHI | 4/4 (PB) | 51p1 | 97.7 | CDR | 2:3 | .11 | DN4 | JH3b |
| FWR | 6:5 | .004 | |||||||
| HAZ | VHI | 3/3 (PB) | 51p1 | 99.1 | CDR | 1:1 | .4 | D21-9 | JH5b |
| FWR | 1:0 | .19 | |||||||
| LC4 | VHIV | 4/6 (BM) 4/4 (PB) | VH4.21 | 95.6 | CDR FWR | 4:2 3:4 | .19 .0002 | DA1/D22-12 | JH2 |
| SEL | VHIII | 9/10 (LN) | DP51 | 95.2 | CDR | 6:2 | .13 | DN1 | JH6b |
| FWR | 3:8 | .00005 | |||||||
| MS | VHIII | 5/6 (BM) 4/4 (PB) | DP47 | 93.1 | CDR FWR | 9:1 4:7 | .026 .00005 | D4 | JH5a |
| Patient . | VH Family . | Tumor Seq/ Clones Seq (Source) . | VH Gene . | % Homology . | R:S Mutations . | P* . | D Gene . | JH Gene . | |
|---|---|---|---|---|---|---|---|---|---|
| SS | VHI | 4/4 (PB) | 51p1 | 99.0 | CDR | 2:0 | .27 | DN4 | JH4b |
| FWR | 2:1 | .1 | |||||||
| SEG | VHI | 4/5 (BM) 2/3 (PB) | 51p1 | 96.3 | CDR FWR | 3:3 3:3 | .25 .004 | DK1 | JH4b |
| LC2 | VHI | 6/8 (PB) | 51p1 | 95.6 | CDR | 4:3 | .14 | DXP1 | JH4b |
| FWR | 8:7 | .0008 | |||||||
| LC3 | VHI | 4/4 (PB) | 51p1 | 97.7 | CDR | 2:3 | .11 | DN4 | JH3b |
| FWR | 6:5 | .004 | |||||||
| HAZ | VHI | 3/3 (PB) | 51p1 | 99.1 | CDR | 1:1 | .4 | D21-9 | JH5b |
| FWR | 1:0 | .19 | |||||||
| LC4 | VHIV | 4/6 (BM) 4/4 (PB) | VH4.21 | 95.6 | CDR FWR | 4:2 3:4 | .19 .0002 | DA1/D22-12 | JH2 |
| SEL | VHIII | 9/10 (LN) | DP51 | 95.2 | CDR | 6:2 | .13 | DN1 | JH6b |
| FWR | 3:8 | .00005 | |||||||
| MS | VHIII | 5/6 (BM) 4/4 (PB) | DP47 | 93.1 | CDR FWR | 9:1 4:7 | .026 .00005 | D4 | JH5a |
*P is the probability for obtaining the observed number of R mutations by chance. The P values were determined with the binomial probability model by analyzing all mutations from each set of clonally related transcripts together (counting each mutation only once). However, the P values were not significantly different when each clone was analyzed separately (data not shown).